CortexinКортексин
What is it?
A tissue-derived mixture of small peptides from animal cerebral cortex, studied as a neuroprotective preparation. It is a mixture rather than one defined peptide.
Identity / background source ↗
Research context
An open clinical report on brain ischemia is linked below. This disease-specific report does not test sleep architecture or validate the personal wearable diary.
- Working classification
- Peptide preparation
- Research collection
- Neuropeptide research · editorial grouping
- Institutional provenance
- Not established for this compound record
- Last evidence review
- Full evidence review pending; source-check scope appears with each publication below.
What do we know?
- Human research
- —Open clinical report
- Study methods
- —Uncontrolled analysis
- Independent replication
- —Not assessed
- Source access
- —English abstract
- Safety evidence
- —Not assessed
These are independent review fields, not a rating. Missing evidence in this starter does not mean no research exists.
Linked sources
Separate personal WHOOP observation ↗ — uncontrolled n=1 data; not included as clinical evidence.
Explore the research map and unresolved leads ↗
Neuroprotective effects of peptides bioregulators in people of various age
R. S. Umnov, N. S. Linkova, V. Kh. Khavinson · Adv Gerontol. 26(4):671–678. PMID 24738258
A gateway review comparing polypeptide complexes (Cortexin and Cerebrolysin) with short peptides (Semax, Cortagen and Pinealon). It discusses older populations and cellular mechanisms; the abstract supplies no trial-quality assessment.
- Population / setting
- Review of earlier research
- What was checked
- Indexed English abstract checked; Russian full text not retrieved.
Limitations & review scope
- Source-linked does not mean a completed risk-of-bias review.
- A review is not an independent clinical replication; proposed mechanisms do not establish efficacy or safety.
Source checked 2026-09-27. This is a source-linked record, not a completed evidence review.
CHRONAS: pilot study of chronic sleep disorders in patients with chronic cerebral ischemia
M. V. Putilina, N. I. Shabalina · Zh Nevrol Psikhiatr Im S S Korsakova 124(4):118–126
Prospective pilot report using sleep, sleepiness and other clinical questionnaires. The abstract describes changes after treatment, but does not describe a randomized untreated control.
- Population / setting
- 50 patients with chronic cerebral ischemia and comorbidities
- What was checked
- English/Russian abstract checked. No wearable sleep-stage results are inferred.
Limitations & review scope
- Clinical population differs from healthy maritime shift workers.
- Before/after change does not isolate a treatment effect.
- Questionnaires cannot validate the personal WHOOP REM/SWS observations.
Source checked 2026-09-27. This is a source-linked record, not a completed evidence review.
An open clinical trial of cortexin in treatment of brain ischemia
V. V. Mashin, L. A. Belova, O. I. Chaplanova, A. F. Khusnullina, A. M. Manasian · Zh Nevrol Psikhiatr Im S S Korsakova. 114(9):49–52
The authors describe before/after cognitive, affective, and neurological changes in an open treatment analysis.
- Population / setting
- Analysis of 500 patients with stage II brain ischemia
- What was checked
- PubMed record and English abstract checked. Open interventional report; grouped here with uncontrolled observational evidence.
Limitations & review scope
- No untreated comparison is described in the abstract.
- The analysis sample is 500; the larger screening population is not the analyzed sample.
- This paper did not measure wearable sleep stages and cannot validate the n=1 diary.
Source checked 2026-09-27. This is a source-linked record, not a completed evidence review.