Intranasal Cortexin and statokinetic tolerance in volunteers
L. G. Buynov, L. A. Sorokina, I. M. Voeykov, P. D. Shabanov · 2014 · Reviews on Clinical Pharmacology and Drug Therapy 12(4):67–71
Indexed 2026-11-09.
Related evidence maps: Military & occupational ↗
Reported findings and study design
The authors reported 1.40–1.44-fold changes on selected stabilography measures and longer motion tolerance. The findings do not measure brain uptake.
Modified Coriolis acceleration test, Bondarevsky balance test and computer stabilography after a ten-day course and during follow-up.
Dose, route and schedule
Intranasal Cortexin 0.25 mg per nostril twice daily, eight hours apart, for ten days, 10 mg total. The paper does not specify the final reconstitution volume.
Protocol source ↗ · Original article, methods and Tables 1–2
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Coriolis motion tolerance | 96.2±3.8 → 151.6±7.4 s | Saline: 90.0±4.5 → 86.5±6.8 s. The paper marks the within-arm change with Cortexin. |
| Static balance | 21.3 → 27.5 s | Cortexin arm in the Bondarevsky test. |
| Selected stabilography measures | 1.40–1.44-fold reported changes | The authors also reported 1.22–1.24-fold reductions in center-of-gravity amplitude and asymmetry. |
| Follow-up | Effect described through 30 days | Other measures showed no clear difference in change. |
Small selected volunteer population. Exact allocation, protocol differences from related vestibular reports and independent replication require additional verification.
Source for the extracted data ↗ · Checked 2026-11-09
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Small selected volunteer population. Exact allocation, protocol differences from related vestibular reports and independent replication require additional verification.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original article, methods and Tables 1–2
Review depth: Reported methods, results and evidence limitations
Source access and review scope
Original article, methods and Tables 1–2
Recorded source-check date: 2026-11-09. This date does not imply a completed systematic review.
Source type: Reviews on Clinical Pharmacology and Drug Therapy 12(4):67–71
Open original source or index record ↗
DOI: 10.17816/RCF12467-71
Citation and original source
Original source: L. G. Buynov, L. A. Sorokina, I. M. Voeykov, P. D. Shabanov. Intranasal Cortexin and statokinetic tolerance in volunteers Reviews on Clinical Pharmacology and Drug Therapy 12(4):67–71 2014.
Molekul research summary: https://molekul.io/research/cortexin-buynov-vestibular-2014. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry