Blinded rat stroke comparison of four peptide preparations
L. Zhang et al. · 2019 · Journal of the Neurological Sciences 398:22–26
Indexed 2026-11-09.
Related evidence maps: Military & occupational ↗
Reported findings and study design
Only Cerebrolysin improved measured functional outcomes versus saline. The other hydrolysates had no significant functional effect and no treatment reduced lesion volume significantly.
Prospective, randomized and blinded comparisons of saline, Cognistar, Cerebrolysat, Cortexin and Cerebrolysin. Serial neurological testing through day 28.
Dose, route and schedule
Daily intraperitoneal doses for ten days starting four hours after occlusion: Cognistar, Cerebrolysat and Cerebrolysin 2.5 mL/kg each, Cortexin 1.7 mg/kg or saline 1 mL per rat. One methods line repeats Cerebrolysin where the abstract and other sections identify Cerebrolysat.
Protocol source ↗ · Journal of the Neurological Sciences 398:22–26
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Serial functional testing | Cerebrolysin improved outcomes; Cortexin, Cerebrolysat and Cognistar did not show a comparable significant benefit | Figure 1. Neurological severity, adhesive removal and foot-fault testing. |
| Lesion volume | No significant improvement versus saline in any treatment group | Functional and histological outcomes are separate. |
Animal ischemia results do not transfer between differently manufactured formulations.
Source for the extracted data ↗ · Checked 2026-11-09
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Animal ischemia results do not transfer between differently manufactured formulations.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Journal of the Neurological Sciences 398:22–26
Review depth: Reported methods, results and evidence limitations
Source access and review scope
Journal of the Neurological Sciences 398:22–26
Recorded source-check date: 2026-11-09. This date does not imply a completed systematic review.
Source type: Journal of the Neurological Sciences 398:22–26
Citation and original source
Original source: L. Zhang et al.. Blinded rat stroke comparison of four peptide preparations Journal of the Neurological Sciences 398:22–26 2019.
Molekul research summary: https://molekul.io/research/zhang-brain-hydrolysates-stroke-2019. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Cerebrolysat
A bovine cerebral-cortex hydrolysate described in a manufacturing patent. Cerebrolysin, Cortexin and PPK-V are separate preparations.
Cortexin
A tissue-derived preparation with Russian stroke, cognitive, pediatric and other clinical reports. Study designs vary; the independent stroke review is shown alongside favorable original reports. None validates the personal WHOOP diary.
Cerebrolysin
Porcine brain-derived peptide mixture studied in neurological disease, rehabilitation and laboratory models. Clinical results, composition analyses and unresolved archival leads are separated in this collection.
Cognistar
One of four separately identified preparations in a blinded rat stroke comparison.