Epitalon and Cortexin after acute systemic cold injury
V. V. Kovalev · 2009 · Candidate dissertation author abstract, Tables 1–3
Indexed 2026-11-09.
Related evidence maps: Military & occupational research ↗
Reported findings and study design
In the severe-injury table, day-five neuron-specific enolase was 23.2 ng/mL with both agents and 58.9 ng/mL with standard care. No formal interaction analysis was reported.
Standard care alone or with Epitalon, Cortexin or both. Serial neuron-specific enolase, immune measures and clinical observations.
Dose, route and schedule
The author abstract reports intramuscular Epitalon 10 µg and Cortexin 10 mg daily for ten days, separately or together depending on arm.
Protocol source ↗ · Author’s abstract transcription. Full dissertation and underlying records unavailable.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Severe cold injury · day-five neuron-specific enolase | 23.2 ng/mL combined vs 58.9 standard care | Cortexin alone 35.3; Epitalon alone 45.0 ng/mL. The source marks p<0.05 for Cortexin and the pair versus standard care. |
| Moderate cold injury · day-five neuron-specific enolase | 11.3 ng/mL combined vs 15.1 standard care | Epitalon 14.8 and Cortexin 14.4 ng/mL. Selected small subgroups. |
| Consciousness and immune markers | Faster recovery and altered immune measures described | Original allocation and longer-term functional outcomes remain unresolved. |
This is a patient rehabilitation study. The biomarker changes do not establish cold tolerance in healthy people.
Source for the extracted data ↗ · Checked 2026-11-09
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- A historical treatment comparison with substantial concurrent care, small subgroup sizes and an imperfect source transcription.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Author’s abstract transcription. Full dissertation and underlying records unavailable.
Review depth: Reported methods, results and evidence limitations
Source access and review scope
Author’s abstract transcription. Full dissertation and underlying records unavailable.
Recorded source-check date: 2026-11-09. This date does not imply a completed systematic review.
Source type: Candidate dissertation author abstract, Tables 1–3
Citation and original source
Original source: V. V. Kovalev. Epitalon and Cortexin after acute systemic cold injury Candidate dissertation author abstract, Tables 1–3 2009.
Molekul research summary: https://molekul.io/research/kovalev-epitalon-cortexin-cold-injury-2009. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Epitalon
Synthetic AEDG has direct human hormone and retinal findings. Long-term Epithalamin mortality studies concern the extract and are kept separate.
Cortexin
A tissue-derived preparation with Russian stroke, cognitive, pediatric and other clinical reports. Study designs vary; the independent stroke review is shown alongside favorable original reports. None validates the personal WHOOP diary.