Potapov–Shustov: pharmacological correction of delayed neuropathy in rats
P. K. Potapov, E. B. Shustov, V. Ya. Apchel, A. N. Smirnov, A. S. Melekhova, M. V. Melnikova, V. A. Basharin, A. A. Bondarenko · 2026 · Bulletin of the Russian Military Medical Academy. 2026;28(1):33–44
Published 2026-03-25.
Reported findings and study design
Rat experiment with day-30 neuromuscular measurements; compound identities and group denominators need full-paper confirmation.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Aminoethanol derivative and citicoline | Favorable responses depended on the experimental model. | |
| Unfavorable response | An inositol derivative worsened selected neuromuscular findings in some animals. |
Not every tested agent showed benefit. No human efficacy estimate or equivalence with ADK-17/FDES established.
Source for the extracted data ↗ · Checked 2026-11-06
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Animal findings do not establish human protection or clinical neuropathy benefit.
- The exact aminoethanol preparation is not sufficiently identified to equate it with ADK-17 or FDES.
- Group flow and agent-specific numerical outcomes require full text.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original publisher abstract and references
Review depth: Abstract, authors and citation trail checked; full tables not recovered
Source access and review scope
Original abstract; no quantitative treatment effect extracted.
Recorded source-check date: 2026-11-06. This date does not imply a completed systematic review.
Source type: Original preclinical journal publication
Open original source or index record ↗
DOI: 10.17816/brmma691737
Citation and original source
Original source: P. K. Potapov, E. B. Shustov, V. Ya. Apchel, A. N. Smirnov, A. S. Melekhova, M. V. Melnikova, V. A. Basharin, A. A. Bondarenko. Potapov–Shustov: pharmacological correction of delayed neuropathy in rats Bulletin of the Russian Military Medical Academy. 2026;28(1):33–44 2026.
Molekul research summary: https://molekul.io/research/shustov-potapov-neuropathy-2026. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Aminoethanol derivatives
A collection of chemically distinct aminoethanol candidates: the diethylaminoethanol-derived FDES and the dimethylaminoethanol-derived ADK-17 program. Animal cognition, neuroprotection, pharmacokinetics and safety reports are separated by preparation. These names do not identify one interchangeable compound.
Polyprenols
A collection covering distinct plant-polyprenol preparations. Ropren from European spruce appears in the Russian POLYNCOR clinical program and a mouse demyelination study; Siberian-fir polyprenols appear in Shustov’s preclinical work. Botanical source, composition and administration differ. Marine extracts in the related research map are separate preparations.
Cortexin
A tissue-derived preparation with Russian stroke, cognitive, pediatric and other clinical reports. Study designs vary; the independent stroke review is shown alongside favorable original reports. None validates the personal WHOOP diary.