Cortexin: rectal formulation application — WO2026043399A1
Ilya Alekseevich LUGOVIK, Dmitrij Valentinovich DEMCHENKO, Petr Petrovich Rodionov · 2026 · WO2026043399A1 · patent family 98865393
Published 2026-02-26.
Reported patent results
Reported findings
Some neurological and locomotor outcomes improved, but a motor-coordination endpoint remained statistically neutral.
Preclinical rat-pup studies of developmental/neonatal brain injury comparing rectal and injected Cortexin with placebo; group-size tables were not transcribed.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Neurological severity, second series | Median mNSS 6 (2–7.25) with placebo versus 0 in treated groups | Injured rats; both formulations described as improved · p<0.001 versus placebo |
| Horizontal locomotion, second series | Median sectors crossed: 21.5 placebo, 34.5 rectal, 45.5 injected | Intact group: 56; not a human performance measure · p<0.05 rectal and p<0.001 injected versus placebo |
| Rotarod coordination | Treatment groups showed a directional increase in fall latency without significant differences | Neutral treatment comparison retained · p>0.05 |
Different rat exposures and the absence of a significant difference between formulations do not establish equivalence or a human dose. The application supplies no verified human efficacy or approval evidence.
Source for the extracted data ↗ · Checked 2026-11-06
Patent claims and provenance
Formulation. The 2026 international application describes suppositories containing a cerebral-cortex polypeptide complex.
A pending application does not establish an approved route, comparative clinical effectiveness or interchangeability with injected Cortexin.
- Publication
- WO2026043399A1 ↗ · 2026-02-26
- Earliest priority / filing
- 2024-08-23 / 2025-08-21
- Original applicant / assignee
- Geropharm
- Indexed status
- Pending · checked 2026-11-06
- Patent family
- 98865393 · family publications are related filings, not independent studies.
Original title, inventors and related publications
Cortexin rectal suppositories
Inventors: Ilya Alekseevich LUGOVIK; Dmitrij Valentinovich DEMCHENKO; Petr Petrovich Rodionov.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- A pending application does not establish an approved route, comparative clinical effectiveness or interchangeability with injected Cortexin.
- Different rat exposures and the absence of a significant difference between formulations do not establish equivalence or a human dose. The application supplies no verified human efficacy or approval evidence.
- Patents record claimed inventions and supporting disclosures. Publication or grant does not establish clinical efficacy, safety or marketing approval. Members of one patent family and related journal reports can describe the same experiments.
- Status labels are Google Patents index snapshots for the displayed publication or application; the record gives its source-check date. Official registers and every national family member have not been independently checked. These labels do not establish freedom to operate.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original patent text and indexed metadata
Review depth: Claims, selected reported findings and limitations reviewed; supporting experiments not comprehensively appraised.
Related-report group: patent-family-98865393. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original patent publication accessed through Google Patents. Claims, selected reported findings and source limitations checked. The results section identifies the examples, tables and any numerical extraction gaps. No complete experimental audit, prosecution review or legal claim construction was performed.
Recorded source-check date: 2026-11-06. This date does not imply a completed systematic review.
Source type: Patent publication
Citation and original source
Original source: Ilya Alekseevich LUGOVIK, Dmitrij Valentinovich DEMCHENKO, Petr Petrovich Rodionov. Cortexin: rectal formulation application — WO2026043399A1 WO2026043399A1 · patent family 98865393 2026.
Molekul research summary: https://molekul.io/research/patent-wo2026043399a1. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry