USING CORTEXIN TO MANAGE THE CONSEQUENCES OF PERINATAL HYPOXIC BRAIN INJURY IN INFANT RATS
Kuznetsov SV, Kuznetsova NN · 2016 · Zhurnal evoliutsionnoi biokhimii i fiziologii. 2016;52(2):195. PMID 30695499
Postnatal offspring treatment · Pregnancy and offspring evidence review ↗
Reported findings and study design
Narrative findings; numerical extraction incomplete
Cortexin transiently improved EMG spectral structure at day 10, but not amplitude; the EMG benefit was absent at day 30. Intact treated pups developed autonomic and heart-rhythm disturbances. This experiment began after birth.
Day-7 carotid ligation plus hypoxia; Cortexin 1 mg/kg intraperitoneally starting one hour later for ten days. EMG, ECG, respiration and heart-rate variability assessed 10 and 30 days after injury.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| EMG | Transient spectral improvement at day 10; no amplitude benefit; earlier EMG benefit absent at day 30 | |
| Autonomic outcomes | Day-30 autonomic balance favored treated injured animals, but intact treated pups showed disturbances | Direction differed by injury status |
| Respiration | Rate remained higher than intact controls in both injured groups |
Neonatal treatment is not maternal or fetal exposure. Do not summarize this as a pregnancy-safety trial. Mixed benefits, transient effects and adverse physiological changes in intact pups must accompany positive findings. Sample sizes, numerical traces and effect estimates are not available in the checked abstract.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Neonatal treatment is not maternal or fetal exposure. Do not summarize this as a pregnancy-safety trial.
- Mixed benefits, transient effects and adverse physiological changes in intact pups must accompany positive findings.
- Sample sizes, numerical traces and effect estimates are not available in the checked abstract.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Publication record and available text
Review depth: Indexed original abstract; full methods and outcome tables not recovered
Related-report group: pregnancy-cortexin-neonatal-2016. Reports in this group are not assumed to be independent trials.
Source access and review scope
Indexed original abstract; full methods and outcome tables not recovered
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal publication
Citation and original source
Original source: Kuznetsov SV, Kuznetsova NN. USING CORTEXIN TO MANAGE THE CONSEQUENCES OF PERINATAL HYPOXIC BRAIN INJURY IN INFANT RATS Zhurnal evoliutsionnoi biokhimii i fiziologii. 2016;52(2):195. PMID 30695499 2016.
Molekul research summary: https://molekul.io/research/pregnancy-cortexin-neonatal-2016. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry