Cortexin in radiation-accident responders: Bioregulation follow-up
V. A. Sorkin · 2009 · Kirov Military Medical Academy dissertation; VMA.03.12.08.0910/0226
Related evidence maps: Military & occupational ↗
Reported findings and study design
At 12 months, reported memory complaints in the two 20-day-course group fell from 93.3% to 33.3%, versus 93.3% to 91.7% in the comparison group. Repeat-course selection limits attribution.
165 Chernobyl response workers in the reported three initial groups (55, 50 and 60); five follow-up subgroups after repeat-course selection
Dose, route and schedule
Cortexin 10 mg intramuscularly daily in reported 10- or 20-day courses. Selected subgroups received a second course at six months. The comparison group received usual care without Cortexin.
Protocol source ↗ · Author-abstract transcription, selected follow-up methods and Table 3 checked; original scan unavailable
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Memory complaint prevalence | 93.3% → 33.3% with two 20-day courses; 93.3% → 91.7% with usual care | At 12 months; n=30 and n=60 in the displayed groups. |
| Headache prevalence | 93.3% → 43.3% with two 20-day courses; 95.0% → 90.0% with usual care | Table 3; reported symptom prevalence, not headache intensity. |
| Schulte task time | Reported decrease 15.6±1.6 s with two 20-day courses | Other groups: decreases 4.5±1.7 s, 8.1±1.6 s and 10.2±1.4 s; comparison-group relative change 2.3%, nonsignificant. |
| Safety reporting | No complete adverse-event table recovered | The author describes monitoring, but the available follow-up does not establish safety. |
Table 3 · selected 12-month symptom results (%)
| Symptom | 10 days ×1 (n=20) | 20 days ×1 (n=20) | Usual care (n=60) | 10 days ×2 (n=35) | 20 days ×2 (n=30) |
|---|---|---|---|---|---|
| Headache | 95.0 → 70.0 | 100.0 → 65.0 | 95.0 → 90.0 | 94.3 → 62.9 | 93.3 → 43.3 |
| Dizziness | 75.0 → 60.0 | 70.0 → 55.0 | 68.3 → 71.7 | 62.9 → 48.6 | 66.7 → 46.7 |
| Sleep complaint | 80.0 → 50.0 | 75.0 → 45.0 | 75.0 → 75.0 | 65.7 → 42.9 | 66.7 → 36.7 |
| Memory complaint | 90.0 → 60.0 | 95.0 → 50.0 | 93.3 → 91.7 | 94.3 → 40.0 | 93.3 → 33.3 |
Baseline → 12 months. Transcribed values, with corrupted significance glyphs omitted. Repeat-course assignment evolved during follow-up.
The author-abstract table supplies a rehabilitation lead, with nonrandom follow-up and subjective endpoints. This is not a worker enhancement or radiation-protection trial.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Repeat-course subgroups formed during follow-up, not clearly randomized groups. Baseline symptoms differed.
- Self-reported symptoms and cognitive-test results in radiation-accident responders do not establish operational performance in healthy people.
- No systematic longer-term adverse-event table was recovered.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Author-abstract transcription, selected follow-up methods and Table 3 checked; original scan unavailable
Review depth: Reported methods, results and evidence limitations
Source access and review scope
Author-abstract transcription, selected follow-up methods and Table 3 checked; original scan unavailable
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Dissertation
Citation and original source
Original source: V. A. Sorkin. Cortexin in radiation-accident responders: Bioregulation follow-up Kirov Military Medical Academy dissertation; VMA.03.12.08.0910/0226 2009.
Molekul research summary: https://molekul.io/research/sorkin-cortexin-radiation-responders-2009. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry