Pinealon, Cortexin and Deltaran: prenatal-stress conference findings
A. M. Mendzheritskii, G. V. Karantysh · 2014 · X International Congress “Neuroscience for Medicine and Psychology”, Sudak, 2–12 June 2014, pp.233–234
Maternal exposure in animals · Pregnancy and offspring evidence review ↗
Reported findings and study design
Reported findings
The abstract reports 96% survival with Deltaran and 94% with Pinealon, without denominators or an untreated-hypoxia survival rate. Learning favored Deltaran then Pinealon then Cortexin, but contradictory caspase-3 statements remain unresolved.
Maternal intraperitoneal exposure throughout pregnancy. Daily hypobaric hypoxia on gestation days 13–20, 66.41 kPa for three hours. Offspring Morris maze and cortical/brainstem caspase-3 at day 21.
Dose, route and schedule
Maternal doses as printed: Cortexin 1 mg/kg, Pinealon 10 µg/kg, Deltaran 12 µg/100 g body weight; intraperitoneally throughout gestation. The abstract does not resolve whether Deltaran mass means formulation or active peptide. These are historical animal methods.
Protocol source ↗ · Original congress proceedings reproduced by an academic repository; printed pp.233–234 visually checked
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Reported survival | Deltaran 96%; Pinealon 94% | No n, uncertainty, untreated-hypoxia rate or numerical Cortexin survival supplied |
| Latent learning | Authors rank Cortexin < Pinealon < Deltaran | No group mean latency, variance or between-treatment p-values |
| Caspase-3 conflict | Deltaran+hypoxia is described as +144% in cortex and +109% in brainstem, then as remaining at control level | Both statements occur in the same abstract; do not resolve by assumption · First sentence: p<0.0001 and p<0.001, respectively |
| Comparator gap | Seven-group list lacks a hypoxia-only untreated arm | An omitted group may exist, but it cannot be reconstructed from the abstract |
Conference abstract with missing denominators and an internally inconsistent biochemical result; not a clinical trial. Deltaran is a DSIP-containing formulation with glycine; results are not proof for isolated DSIP. Formulation mass versus active-peptide mass is not resolved by this abstract. Shared Rostov authors and models may overlap the 2012 papers and dissertations; no pooled sample or independent-replication count is calculated.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Conference abstract with missing denominators and an internally inconsistent biochemical result; not a clinical trial.
- Deltaran is a DSIP-containing formulation with glycine; results are not proof for isolated DSIP. Formulation mass versus active-peptide mass is not resolved by this abstract.
- Shared Rostov authors and models may overlap the 2012 papers and dissertations; no pooled sample or independent-replication count is calculated.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original PDF
Review depth: Original congress proceedings reproduced by an academic repository; printed pp.233–234 visually checked
Related-report group: rostov-prenatal-peptides-2012-2014. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original congress proceedings reproduced by an academic repository; printed pp.233–234 visually checked
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Conference abstract
Citation and original source
Original source: A. M. Mendzheritskii, G. V. Karantysh. Pinealon, Cortexin and Deltaran: prenatal-stress conference findings X International Congress “Neuroscience for Medicine and Psychology”, Sudak, 2–12 June 2014, pp.233–234 2014.
Molekul research summary: https://molekul.io/research/pregnancy-peptides-sudak-2014. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Pinealon
A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.
Cortexin
A tissue-derived preparation with Russian stroke, cognitive, pediatric and other clinical reports. Study designs vary; the independent stroke review is shown alongside favorable original reports. None validates the personal WHOOP diary.
DSIP
A peptide first characterized in Swiss sleep research and later studied in Soviet/Russian analogue and stress-adaptation programs. Ordinary DSIP, modified analogues and piracetam combinations have distinct evidence.