Intranasal carrier and injected Cortexin in rat seizure models
V. A. Aniol et al. · 2011 · Original journal article, methods and Figures 1–4
Indexed 2026-11-09.
Related evidence maps: Military & occupational research ↗
Reported findings and study design
The intranasal carrier arm did not reproduce the significant delayed effect seen at 1.0 mg/kg intraperitoneally.
Acute pentylenetetrazole convulsions and chronic kindling. Saline and diazepam controls.
Dose, route and schedule
Intraperitoneal Cortexin at 0.015, 0.15 or 1.0 mg/kg. Separate intranasal calcium-carbonate formulation at 0.15 mg/kg.
Protocol source ↗ · Original journal article, methods and Figures 1–4
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Intranasal arm | No significant protection on the reported key chronic endpoint | Carrier-bound formulation tested at 0.15 mg/kg. |
| Injected arm | Less severe provoked seizures after a ten-day rest | 1.0 mg/kg intraperitoneally in the applicable kindling schedule. |
| Acute provocation | Protocol-specific effects | Route and dose were not matched for estimating bioavailability. |
These results concern seizure assays. Neither route establishes a pharmacokinetic estimate or a human outcome.
Source for the extracted data ↗ · Checked 2026-11-09
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- These results concern seizure assays. Neither route establishes a pharmacokinetic estimate or a human outcome.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original journal article, methods and Figures 1–4
Review depth: Reported methods, results and evidence limitations
Source access and review scope
Original journal article, methods and Figures 1–4
Recorded source-check date: 2026-11-09. This date does not imply a completed systematic review.
Source type: Original journal article, methods and Figures 1–4
Citation and original source
Original source: V. A. Aniol et al.. Intranasal carrier and injected Cortexin in rat seizure models Original journal article, methods and Figures 1–4 2011.
Molekul research summary: https://molekul.io/research/cortexin-aniol-seizure-2011. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry