EpithalaminЭпиталамин
What is it?
A pineal-gland tissue extract containing a mixture of peptides. Human aging and melatonin studies of this preparation must be distinguished from research on synthetic Epitalon (AEDG).
Research context
A pineal-gland tissue extract containing a mixture of peptides. Human aging and melatonin studies of this preparation must be distinguished from research on synthetic Epitalon (AEDG).
- Working classification
- Tissue-derived polypeptide complex
- Research collection
- Peptide bioregulation · editorial grouping
- Institutional provenance
- Not established for this compound record
- Last evidence review
- Full evidence review pending; source-check scope appears with each publication below.
What do we know?
- Human research
- —Clinical reports linked; see study-specific limitations
- Study methods
- —Original reports separated from narrative reviews and patents
- Independent replication
- —Independent replication not established by this collection
- Source access
- —Linked abstracts, analytical papers, reviews and patents; individual scope shown below
- Safety evidence
- —Incomplete assessment; findings do not establish safety for personal use
These are independent review fields, not a rating. Missing evidence in this starter does not mean no research exists.
Where this preparation fits.
Pineal gland: the molecular link
Epithalamin → Epitalon / AEDG
The 2017 analytical study detected AEDG in pineal polypeptide complex, after its earlier design from amino-acid composition.
Clinical boundary
The 12-year cardiovascular report, 266-person gerontology report and melatonin observations concern Epithalamin extract.
Extract findings do not establish equivalent benefits for synthetic AEDG. Check cohort overlap, methods and independent replication before interpreting longevity claims.
Related preparations
The contextual sources below can concern a related extract, review or molecular link. They are not all direct studies of this profile’s compound.
Linked sources
Explore the research map and unresolved leads ↗
Peptide bioregulators: the new class of geroprotectors. Message 2. Clinical studies results
Khavinson VKh, Kuznik BI, Ryzhak GA · Adv Gerontol 26(1):20-37. PMID 24003726
Summarizes clinical work on seven named peptide preparations. Useful for tracing original Russian reports and distinguishing tissue extracts from short peptides.
- Population / setting
- Originating group’s clinical and gerontology literature
- What was checked
- Indexed abstract and citation checked via Europe PMC / PubMed; full methods and risk of bias not appraised.
Limitations & review scope
- Review by investigators in the originating program; not independent replication.
- Clinical findings must be traced to the exact preparation and original study.
Source checked 2026-09-29. This is a source-linked record, not a completed evidence review.
Identification of Peptide AEDG in the Polypeptide Complex of the Pineal Gland
Khavinson VK, Kopylov AT, Vaskovsky BV, Ryzhak GA, Lin'kova NS · Bull Exp Biol Med 164(1):41-43. PMID 29124531
Mass spectrometry/HPLC and selective reaction monitoring identified AEDG in the pineal complex. This supplies a molecular link to the synthetic tetrapeptide.
- Population / setting
- Pineal polypeptide-complex composition
- What was checked
- Indexed abstract and citation checked via Europe PMC / PubMed; full methods and risk of bias not appraised.
Limitations & review scope
- Detection in an extract does not prove that this peptide accounts for all extract effects.
- Composition analysis does not establish clinical equivalence.
Source checked 2026-09-29. This is a source-linked record, not a completed evidence review.
Peptides of pineal gland and thymus prolong human life
Khavinson VKh, Morozov VG · Neuro Endocrinol Lett 24(3-4):233-240. PMID 14523363
The investigators reported differences in illness and mortality across extract-treatment groups and controls. This is research on Thymalin and Epithalamin, including their combination.
- Population / setting
- 266 older people followed for 6–8 years
- What was checked
- Indexed abstract and citation checked via Europe PMC / PubMed; full methods and risk of bias not appraised.
Limitations & review scope
- Allocation, attrition, baseline balance and outcome ascertainment require full-text appraisal.
- Do not transfer these outcomes to Vilon, Thymogen or synthetic Epitalon; independent replication is not established here.
Source checked 2026-09-29. This is a source-linked record, not a completed evidence review.
Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people
Korkushko OV, Khavinson VKh, Shatilo VB, Magdich LV · Bull Exp Biol Med 137(4):389-391. PMID 15452611
Reported changes in nighttime melatonin that differed according to baseline pineal activity.
- Population / setting
- Older adults; plasma melatonin before and after treatment
- What was checked
- Indexed abstract and citation checked via Europe PMC / PubMed; full methods and risk of bias not appraised.
Limitations & review scope
- Before/after hormone measurements do not establish sleep-stage or clinical sleep benefit.
- The preparation is Epithalamin, not isolated AEDG.
Source checked 2026-09-29. This is a source-linked record, not a completed evidence review.
Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging
Korkushko OV, Khavinson VKh, Shatilo VB, Antonyuk-Shcheglova IA · Bull Exp Biol Med 142(3):356-359. PMID 17426848
The abstract describes a randomized comparison and reports favorable long-term cardiovascular and mortality outcomes with the pineal extract.
- Population / setting
- Older patients with coronary disease and accelerated cardiovascular aging; 12-year follow-up
- What was checked
- Indexed abstract and citation checked via Europe PMC / PubMed; full methods and risk of bias not appraised.
Limitations & review scope
- Allocation methods, follow-up completeness and absolute event counts require full-text appraisal.
- Potential overlap with later follow-up reports must be checked; this is not an Epitalon trial.
Source checked 2026-09-29. This is a source-linked record, not a completed evidence review.