Cortexin and childhood autism: Larkina and Khaletskaya’s preschool comparison
E. V. Larkina, O. V. Khaletskaya · 2014 · Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(12):94–98. PMID 25726787.
Reported findings and study design
Active-comparator study with reassessment three months after rehabilitation began. Both autism arms received speech-language and psychoeducational support.
Dose, route and schedule
The paper reports 10 mg intramuscular Cortexin once daily for 10 days in the autism arm. The comparator received age-adjusted risperidone. Both arms received multidisciplinary rehabilitation. This describes the historical study.
Protocol source ↗ · Original journal methods
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Overall speech development | No statistically significant change | p = 0.119 |
| Social communication | No statistically significant change | p = 0.058 |
| Verb selection and use | Improvement reported on an individual task | p < 0.001 (printed as 0.000) |
| Noun selection and use | Improvement reported on an individual task | p = 0.001 |
| Word association | Improvement reported on an individual task | p = 0.019 |
| Overall speech development in the risperidone arm | A statistically significant within-arm change was reported | p = 0.039 |
| Social communication in the risperidone arm | No statistically significant within-arm change | p = 0.765 |
Separate within-arm p-values do not test superiority. The reported arm counts sum to 45 despite a stated autism cohort of 40. The 2015 dissertation describes the same research program.
Source for these results ↗ · Reviewed 2026-11-10
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The article reports 40 autistic children, but lists 23 receiving Cortexin and 22 receiving risperidone. The autism arm denominators cannot be reconciled.
- All children received speech-language and psychoeducational rehabilitation. The reported p-values compare each arm with its own baseline. Allocation concealment and masking were not established.
- Multiple task comparisons, limited follow-up and missing autism-arm adverse-event counts limit interpretation.
Related publications may cover the same research program or participants.
Source access
Original Russian journal text and reported outcome statistics checked. The 2015 dissertation is a companion report from the same program.
Source reviewed 2026-11-10.
Citation and original source
Original source: E. V. Larkina, O. V. Khaletskaya. Cortexin and childhood autism: Larkina and Khaletskaya’s preschool comparison Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(12):94–98. PMID 25726787. 2014.
Molekul research summary: https://molekul.io/research/cortexin-larkina-autism-2014. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry