Effect of Cortexin on neuroplasticity in multiple sclerosis
S. V. Kotov, T. I. Yakushina, V. Yu. Lizhdvoy · 2009 · Effective Pharmacotherapy. Neurology and Psychiatry. 2009;(3):14–16
What does this source report?
EDSS did not change significantly. Beck depression scores fell from 17.6±1.3 to 12.9±1.4 and EQ-5D rose from 0.41±0.07 to 0.73±0.03 (reported p<0.05). These are uncontrolled symptom and quality-of-life observations, not evidence of remyelination.
- Population and setting
- 20 adults with relapsing-remitting MS in stable remission; 7 men and 13 women, ages 27–43
- Evidence type
- Uncontrolled human report
- Preparation
- See the original report; formulation details require verification.
- Source language
- Russian
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Open prospective study without a control group, randomization or blinding.
- Participants were already in remission; stable EDSS does not demonstrate prevention of progression.
- No adverse events were observed in this small sample; safety and disease modification are not established.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Publisher article and Russian PDF
Review depth: Full article reviewed
Source access and review scope
Source text reviewed at the access level stated; no independent verification of patient data.
Recorded source-check date: 2026-10-03. This date does not imply a completed systematic review.
Cite and trace this record
Original source: S. V. Kotov, T. I. Yakushina, V. Yu. Lizhdvoy. Effect of Cortexin on neuroplasticity in multiple sclerosis Effective Pharmacotherapy. Neurology and Psychiatry. 2009;(3):14–16 2009.
Molekul research summary: https://molekul.io/research/cortexin-ms-2009. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry