Shabanov’s rat peptide behavior comparison: Oleyl-Cortagen and Cortexin
P. D. Shabanov et al. · 2009 · Medical Academic Journal, 2009; publisher article 9357
Related evidence maps: Military & occupational ↗
Reported findings and study design
Oleyl-Cortagen and Cortexin increased hypothalamic self-stimulation by 32% and 23%, respectively. Cortagen and Cerebrolysin did not change this outcome; other behavioral assays differed.
192 Wistar rats, 200–220 g; methods describe at least 10–12 per group across a behavioral test battery
Dose, route and schedule
Intraperitoneal doses: 1 mg/kg Cortexin, Cerebrolysin, Cortagen, Oleyl-Cortagen, Noopept and Dilept; 0.1 mg/kg Deltaran, Semax and Selank; piracetam 200 mg/kg. General behavior tests 30–40 minutes post-dose; self-stimulation measured 15–20 minutes post-dose.
Protocol source ↗ · Publisher full-text methods and results narrative; original PDF tables not recovered
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Oleyl-Cortagen · self-stimulation | +32% in lateral-hypothalamic pedal presses | Reported relative increase, not an endurance or strength endpoint. |
| Cortexin · self-stimulation | +23% in lateral-hypothalamic pedal presses | Reported relative increase; no direct statistical test versus Oleyl-Cortagen supplied in narrative. |
| Cortagen and Cerebrolysin · self-stimulation | No change reported in pedal-press frequency | At the systemic doses in this article; does not contradict the separate central-dose comparisons. |
| Open-field behavior | Oleyl-Cortagen increased horizontal and vertical movement but halved hole exploration | Cortexin and Cerebrolysin increased horizontal movement; Dilept reduced horizontal and vertical movement. |
| Noopept, Semax, Selank and Dilept · vertical activity | Reduced vertical movements reported | Compound-specific rat behavior at the stated doses, not a measure of human alertness. |
| Porsolt immobility | Lower with Oleyl-Cortagen, Dilept and Cortexin; higher with Cerebrolysin, Semax, Cortagen and Selank | This unweighted behavior assay is distinct from loaded endurance swimming. Piracetam was inactive in the report. |
| Deltaran · grooming | Grooming reactions increased | The report tested Deltaran, a DSIP-containing formulation; this observation is not assigned to isolated DSIP. |
Opposing effects across assays are informative. Electrical self-stimulation and immobility are behavior readouts, and neither establishes improved human motivation or endurance.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Multiple behavioral comparisons, endpoint-specific group sizes and precise uncertainties need table recovery.
- Deltaran is the tested DSIP-containing formulation; no result for isolated DSIP can be inferred.
- The 2015 dissertation used separate doses/routes; it is not confirmed as independent replication of every experiment.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Publisher full-text methods and results narrative; original PDF tables not recovered
Review depth: Reported methods, results and evidence limitations
Source access and review scope
Publisher full-text methods and results narrative; original PDF tables not recovered
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Original journal article
Citation and original source
Original source: P. D. Shabanov et al.. Shabanov’s rat peptide behavior comparison: Oleyl-Cortagen and Cortexin Medical Academic Journal, 2009; publisher article 9357 2009.
Molekul research summary: https://molekul.io/research/shabanov-oleyl-cortagen-2009. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Oleyl-Cortagen
A lipid-modified Ala–Glu–Asp–Pro tetrapeptide evaluated in rat behavioral studies. Cortagen is the unmodified peptide and Cortexin is a separate tissue mixture.
Cortagen
Listed in the 2013 short-peptide review under the authors’ proposed brain target. This historical label is not an established indication. Underlying studies need individual review.
Cortexin
A tissue-derived preparation with Russian stroke, cognitive, pediatric and other clinical reports. Study designs vary; the independent stroke review is shown alongside favorable original reports. None validates the personal WHOOP diary.
Cerebrolysin
Porcine brain-derived peptide mixture studied in neurological disease, rehabilitation and laboratory models. Clinical results, composition analyses and unresolved archival leads are separated in this collection.
Semax
ACTH-fragment-derived peptide with clinical stroke and optic-nerve reports, healthy-volunteer imaging and preclinical neuroregulation research. Precursor, patent and dissertation sources remain separately labeled.
Selank
Tuftsin-derived peptide investigated in anxiety comparisons, stress models and neurochemical assays. Its clinical and laboratory evidence are kept distinct from unverified archival claims.
Noopept
A defined synthetic dipeptide derivative connecting nootropic research with experimental environmental adaptation. Human chamber studies, clinical EEG reports and preclinical mechanisms address different questions; none establishes safe hazardous-work use.
Dilept
A neurotensin-related peptidomimetic (GZR-123), with a small psychiatric pilot, animal metabolite and withdrawal research, and a separate occupational environmental comparison.
DSIP
A peptide first characterized in Swiss sleep research and later studied in Soviet/Russian analogue and stress-adaptation programs. Ordinary DSIP, modified analogues and piracetam combinations have distinct evidence.
Piracetam
Piracetam, marketed as Nootropil, connects the original nootropic concept with Soviet clinical adoption and later operator, hypoxia and maritime research. Healthy-volunteer experiments, clinical reviews and combination proposals answer different questions.