Cortexin and Dalargin during a 21-day rat swimming series
N. N. Karkishchenko, V. V. Uyba, V. N. Karkishchenko, E. B. Shustov, K. V. Kotenko, S. L. Lyublinskiy · 2014 · Essays on Sports Pharmacology, Vol. III, Vectors of Pharmacoregulation, Chapter 5, pp. 148–151, Table 9
Indexed 2026-11-09.
Related evidence maps: Sports performance ↗
Reported findings and study design
First-swim means reached 227.25 s with Cortexin and 218.0 s with Dalargin on day 21, versus 71.9 s in controls. Starting means already differed.
Repeated forced swimming with a 7%-body-mass load. Three swims per test session measured persistence and recovery. Tests before treatment, on days 7, 14 and 21, and one week after dosing.
Dose, route and schedule
Daily rectal Cortexin 5 mg/kg or Dalargin 0.56 mg/kg for 21 days, in separate arms.
Protocol source ↗ · Original publication and selected methods and results checked
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Cortexin · first swim | 84.3±3.9 → 227.25±4.5 s | Day 0 to 21. Second and third day-21 swims: 159.0±4.28 and 204.6±10.9 s. |
| Dalargin · first swim | 79.7±5.4 → 218.0±6.6 s | Day 0 to 21. Second and third day-21 swims: 187.3±5.4 and 181.6±6.7 s. |
| Control · first swim | 63.8 → 71.9±3.9 s | Day 0 to 21. Control rose to 91.4±3.3 s on day 28. |
| Cortexin · recovery index | Transient deterioration at day 14 | Recovery and first-swim duration are separate outcomes. |
The arms compare the peptides individually. They do not test a Cortexin–Dalargin combination.
Source for the extracted data ↗ · Checked 2026-11-09
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Unequal baseline results, non-equivalent doses and repeated training exposure limit between-group interpretation.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original publication and selected methods and results checked
Review depth: Reported methods, results and evidence limitations
Source access and review scope
Original publication and selected methods and results checked
Recorded source-check date: 2026-11-09. This date does not imply a completed systematic review.
Source type: Essays on Sports Pharmacology, Vol. III, Vectors of Pharmacoregulation, Chapter 5, pp. 148–151, Table 9
Citation and original source
Original source: N. N. Karkishchenko, V. V. Uyba, V. N. Karkishchenko, E. B. Shustov, K. V. Kotenko, S. L. Lyublinskiy. Cortexin and Dalargin during a 21-day rat swimming series Essays on Sports Pharmacology, Vol. III, Vectors of Pharmacoregulation, Chapter 5, pp. 148–151, Table 9 2014.
Molekul research summary: https://molekul.io/research/shustov-volume3-cortexin-dalargin-swim-2014. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Cortexin
A tissue-derived preparation with Russian stroke, cognitive, pediatric and other clinical reports. Study designs vary; the independent stroke review is shown alongside favorable original reports. None validates the personal WHOOP diary.
Dalargin
A Soviet synthetic opioid hexapeptide investigated in cytoprotection, stress, hypoxia, ischemia and trauma. Its enkephalin lineage is distinct from organ-derived peptide bioregulators; historical proposals and laboratory effects are not established clinical indications.