Pinealon versus Cortexin after prenatal hypoxia: dissertation methods
V. A. Abramchuk · 2013 · Candidate dissertation author’s abstract. St. Petersburg, 2013; “Peptide regulation of neurodegenerative processes in young and old rats”
Maternal exposure in animals · Pregnancy and offspring evidence review ↗
Reported findings and study design
Reported findings
For gestation-day-13–20 hypoxia, third-day maze latency was 34.5±3.9 seconds with Pinealon, 58.37±3.22 with Cortexin and 121.8±19.01 with saline. Cortexin-only offspring also performed worse than intact controls. Source is an author-abstract transcription, not an authenticated full thesis.
Maternal treatment throughout gestation; hemic and hypoxic injury windows compared. Offspring killed at days 21–23; Morris maze, brain HPLC monoamines and fluorimetric caspase-3. Older-rat carotid occlusion is a separate experiment.
Dose, route and schedule
Pinealon 10 µg/kg or Cortexin 1 mg/kg administered maternally throughout gestation; saline controls; injury windows include gestation days 1–10, 18–20 and 13–20. Separate older-rat pretreatment doses must not be substituted for the prenatal schedule.
Protocol source ↗ · Author-abstract text and Table 2 reproduced by Medical-Diss; original full dissertation and table scan not authenticated
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Third-day maze latency, late prenatal hypoxia | Pinealon 34.5 ± 3.9 s; Cortexin 58.37 ± 3.22 s; saline 121.8 ± 19.01 s | Intact 18.72 ± 1.73 s; table n=15/(60), n=15/(60), n=7/(28), intact n=18/(72) · Third testing day · Table # denotes within-group day 3 versus day 1, not a treatment-versus-control test |
| Cortexin without hypoxia | 38.55 ± 2.34 s versus intact 18.72 ± 1.73 s | Author reports 106% longer latency; no benefit in this healthy comparison · Third testing day · p<0.01 in narrative |
| Survival | Pinealon reduced stillbirths in some models; residual loss remained in the longest hypoxia window | Exact independent dam denominators and complete cohort flow unresolved |
Third-party transcription of the author’s abstract, not the complete original thesis; verify the scan before relying on uncertain table formatting. Two n values per prenatal group are not adequately explained; animal, dam, litter and repeated-trial denominators cannot be reconciled. Related journal/conference publications may share these cohorts. Within-group learning p-values do not demonstrate between-drug superiority. The prose and table indicate incomplete protection, including impaired Cortexin-only learning; neither compound has demonstrated human pregnancy safety here.
Source for the extracted data ↗ · Checked 2026-11-08
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Third-party transcription of the author’s abstract, not the complete original thesis; verify the scan before relying on uncertain table formatting.
- Two n values per prenatal group are not adequately explained; animal, dam, litter and repeated-trial denominators cannot be reconciled.
- Related journal/conference publications may share these cohorts. Within-group learning p-values do not demonstrate between-drug superiority.
- The prose and table indicate incomplete protection, including impaired Cortexin-only learning; neither compound has demonstrated human pregnancy safety here.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Dissertation author-abstract transcription
Review depth: Author-abstract text and Table 2 reproduced by Medical-Diss; original full dissertation and table scan not authenticated
Related-report group: rostov-prenatal-peptides-2012-2014. Reports in this group are not assumed to be independent trials.
Source access and review scope
Author-abstract text and Table 2 reproduced by Medical-Diss; original full dissertation and table scan not authenticated
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Dissertation author-abstract transcription
Citation and original source
Original source: V. A. Abramchuk. Pinealon versus Cortexin after prenatal hypoxia: dissertation methods Candidate dissertation author’s abstract. St. Petersburg, 2013; “Peptide regulation of neurodegenerative processes in young and old rats” 2013.
Molekul research summary: https://molekul.io/research/pregnancy-abramchuk-thesis-2013. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Pinealon
A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.
Cortexin
A tissue-derived preparation with Russian stroke, cognitive, pediatric and other clinical reports. Study designs vary; the independent stroke review is shown alongside favorable original reports. None validates the personal WHOOP diary.