Cortexin modulates OPG/RANK/RANKL and TRPC1 expression in cerebral ischemia-reperfusion injury.
Guven C, Türk A, Koçak S, Zencirci B, Yalcin A, Aydın H, Doğukan M · 2026 · Neurological research. 2026.
Study findings
Cortexin reduced measured oxidative stress and expression of OPG, RANK, RANKL and TRPC1 in rat brain tissue after ischemia/reperfusion.
- Population and setting
- 35 male Wistar rats in five ischemia/reperfusion and comparator groups
- Evidence type
- Animal / experimental
- Source language
- eng
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- Biomarker findings in rats do not establish functional recovery or benefit in human stroke.
- Full methods, blinding and allocation require appraisal.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Abstract-level record
Source access and review scope
Indexed primary-publication abstract checked; full methods and tables not appraised.
Recorded source-check date: 2026-10-08. This date does not imply a completed systematic review.
Citation and original source
Original source: Guven C, Türk A, Koçak S, Zencirci B, Yalcin A, Aydın H, Doğukan M. Cortexin modulates OPG/RANK/RANKL and TRPC1 expression in cerebral ischemia-reperfusion injury. Neurological research. 2026. 2026.
Molekul research summary: https://molekul.io/research/refresh-40783844. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry