Read beyond the abstract.
Original methods can change how a promising result should be understood. This collection tracks recovered evidence and the documents still needed.
Updated 2 October 2026. Publication records are not independent-trial counts. Translations, abridged reprints and overlapping cohorts are identified where possible. “Full text available” describes access; review depth is shown separately.
Bromantane ↗
Clinical methods and attrition recovered
The Neznamov paper describes 15 patients per arm, with only seven placebo participants completing. A separate 40-patient report is now linked. These reports require cohort-overlap checks.
What remains unresolved
Recover mental-fatigue, heat/gas and altitude originals; reconcile the 2009 clinical reports before pooling.
Bemitil ↗
Combination-source links repaired
The Trekrezan–Metaprot animal report and Bromitil pharmacokinetic source are linked. The Pirabel programme now has separate experiment descriptions.
What remains unresolved
The 1991 voyage paper remains abstract-only; ship setting, enrollment, allocation, morbidity definitions and harms need the original. The 130-patient asthenia paper and 1984/1993/1994 proceedings remain retrieval targets.
Kim: hypoxia comparison
48 healthy men aged 20–28 · Drug and placebo exposures separated by 2–3 weeks; four baseline-matched groups
Measures: Laboratory mental and physical performance. Transcription loses some denominators; allocation order and washout adequacy remain unresolved.
Programme source ↗Kim: human pharmacokinetics
18 healthy men aged 21–25; three groups of six · Single-exposure comparison of combination and individual components
Measures: Blood concentration time course. Pharmacokinetics does not establish efficacy or clinical synergy.
Programme source ↗Pirabel: prolonged physical work
78 volunteers aged 18–25; eight baseline-matched groups · Described as double-blind; six-hour cyclic physical-work model
Measures: Dynamic work, endurance and recovery measures. Randomization unconfirmed; no piracetam-only arm. Separate from the subsequent 20-man Bemitil/Sydnocarb experiment.
Programme source ↗Trekrezan ↗
Duplicate cold-study record consolidated
The two records for PMID 18383733 now resolve to one publication. The 75-man cold report remains distinct from animal immune-metabolism work.
What remains unresolved
Retrieve original cold-study tables and Ganapolsky thesis; 2007/2008 cohort overlap and treatment-arm sizes remain unresolved.
B-300 ↗
Separate experiments and source format identified
Mental-fatigue, escalation and environmental tests are listed separately below. A transcription and later institutional history do not constitute independent replication.
What remains unresolved
Recover the original Elistratov thesis, allocation details, complete tables and safety follow-up.
B-300: mental-fatigue comparison
30 active-treatment participants and 10 placebo · Post-educational-workload comparison
Measures: Cognitive tasks and self-rated state. Transcribed summary; allocation, complete baseline tables and missing outcomes require original thesis.
Programme source ↗B-300: activation-versus-accuracy experiment
34 participants in 12/12/10 groups · Separate escalation comparison
Measures: Activation and operator errors. Higher activation did not mean greater accuracy. Not pooled with the fatigue experiment.
Programme source ↗B-300: environmental comparisons
Small groups; arm-by-environment denominators require original verification · Cold, heat and simulated-altitude experiments
Measures: Physical and mental task performance. Historical controls and repeated testing; not a single uniform trial or proof of operational protection.
Programme source ↗Pirabel ↗
Programme and experiment boundaries expanded
The recovered monograph comparison and Kim dissertation transcription are linked. Human pharmacokinetics, training and environmental performance are separated.
What remains unresolved
Recover original experiment publications and complete thesis; clarify overlap with the 78-volunteer monograph programme.
Kim: hypoxia comparison
48 healthy men aged 20–28 · Drug and placebo exposures separated by 2–3 weeks; four baseline-matched groups
Measures: Laboratory mental and physical performance. Transcription loses some denominators; allocation order and washout adequacy remain unresolved.
Programme source ↗Kim: visuomotor learning
40 inexperienced operators; five groups of eight · Described as randomized and double-blind
Measures: Time maintaining a tracking signal in its target area. Small groups and practice effects; not an operational accident or fatigue-safety study.
Programme source ↗Kim: human pharmacokinetics
18 healthy men aged 21–25; three groups of six · Single-exposure comparison of combination and individual components
Measures: Blood concentration time course. Pharmacokinetics does not establish efficacy or clinical synergy.
Programme source ↗Pirabel: prolonged physical work
78 volunteers aged 18–25; eight baseline-matched groups · Described as double-blind; six-hour cyclic physical-work model
Measures: Dynamic work, endurance and recovery measures. Randomization unconfirmed; no piracetam-only arm. Separate from the subsequent 20-man Bemitil/Sydnocarb experiment.
Programme source ↗Bromitil ↗
Previously empty source trail populated
The Krasnykh dissertation transcription identifies the combined-tablet pharmacokinetic research. Animal exposure changes are not evidence of clinical synergy.
What remains unresolved
Obtain the original dissertation and formulation specification; human benefit and combination safety remain unestablished.
Etomerzol ↗
Original experimental publication added
The 2003 publisher record documents rat hypoxia and in-vitro antioxidant work. This supplies a traceable experimental source rather than a name alone.
What remains unresolved
Recover complete methods, preparation chemistry and replication. Do not silently equate Etomerzol with the unresolved Tomerzol name or infer human benefit.
Noopept ↗
Clinical records and environmental methods expanded
The missing Noopept–piracetam publications and encephalopathy citation are linked. The environmental PDF identifies historical controls, small groups and experimental formulations.
What remains unresolved
Clinical comparison full texts remain unavailable; resolve translation/EEG overlap. Verify all environmental table values and arm denominators against a clean original.
Phenotropil ↗
Full-text attrition changes interpretation
The epilepsy paper reports 32 adverse-event discontinuations. TRIUMPH analyzed 1,170 of 2,029 participants after 859 protocol/documentation exclusions.
What remains unresolved
Complete outcome-table, missing-data and funding appraisal; retrieve original toxicology and bioequivalence records. Racemate and isolated enantiomers remain distinct.
Piracetam ↗
Condition-specific review and original trials added
Acute-stroke review, memory-training trial and post-stroke rehabilitation trial now complement the older memory literature. Noopept comparisons are shared sources, not new independent trials.
What remains unresolved
Recover complete original trial methods, harms and overlap with reviews. Historical stroke evidence does not answer healthy-worker cognition.
Kim: hypoxia comparison
48 healthy men aged 20–28 · Drug and placebo exposures separated by 2–3 weeks; four baseline-matched groups
Measures: Laboratory mental and physical performance. Transcription loses some denominators; allocation order and washout adequacy remain unresolved.
Programme source ↗Kim: visuomotor learning
40 inexperienced operators; five groups of eight · Described as randomized and double-blind
Measures: Time maintaining a tracking signal in its target area. Small groups and practice effects; not an operational accident or fatigue-safety study.
Programme source ↗Kim: human pharmacokinetics
18 healthy men aged 21–25; three groups of six · Single-exposure comparison of combination and individual components
Measures: Blood concentration time course. Pharmacokinetics does not establish efficacy or clinical synergy.
Programme source ↗Pirabel: prolonged physical work
78 volunteers aged 18–25; eight baseline-matched groups · Described as double-blind; six-hour cyclic physical-work model
Measures: Dynamic work, endurance and recovery measures. Randomization unconfirmed; no piracetam-only arm. Separate from the subsequent 20-man Bemitil/Sydnocarb experiment.
Programme source ↗Picamilon ↗
2024/2025 publisher texts recovered
Both 2024 reports and the 2025 study are linked with design and analysis-population details. Possible overlap is flagged; no pooled enrollment is presented.
What remains unresolved
Resolve participant overlap with authors or recruitment records; recover Ufa proceedings and swimmer dissertation. A 2011 swimmer PDF is linked; subgroup denominators and cohort overlap remain unresolved.
Semax ↗
Clinical comparison boundaries clarified
The acute-stroke abstract specifies 30 adjunctive-treatment patients and 80 conventional-care controls. Clinical comparisons remain separate from healthy-volunteer imaging.
What remains unresolved
Recover original stroke and optic-nerve papers, allocation, attrition and harms. Imaging changes do not establish cognitive benefit or occupational safety.
Selank ↗
Additional clinical comparison and source discrepancy added
The 70-patient adjunctive phenazepam report is linked. The shortened 2008 reprint conflicts with the indexed abstract on treatment-arm sizes.
What remains unresolved
Obtain the unabridged 2008 journal paper; resolve group sizes, blinding and allocation. Similarity to medazepam does not establish equivalence.