Neuroprotective properties of nootropic dipeptide GVS-111 in in vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress
N. A. Andreeva, E. V. Stel’mashuk, N. K. Isaev, R. U. Ostrovskaya, T. A. Gudasheva, I. V. Viktorov · 2000 · Bull Exp Biol Med. 130(10):969–972
What does this source report?
GVS-111 showed protective effects in oxygen/glucose deprivation and glutamate/oxidative-stress models; piracetam did not attenuate glutamate toxicity in this experiment.
- Population and setting
- Cultured cerebellar granule cells; experimental injury models
- Evidence type
- In vitro
- Preparation
- See the original report; formulation details require verification.
- Source language
- See original publication
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Cell survival is not human clinical neuroprotection.
- The assay-specific piracetam comparison is not a clinical superiority result.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed primary-paper record and abstract checked; full methods and risk of bias not appraised.
Recorded source-check date: 2026-09-29. This date does not imply a completed systematic review.
Cite and trace this record
Original source: N. A. Andreeva, E. V. Stel’mashuk, N. K. Isaev, R. U. Ostrovskaya, T. A. Gudasheva, I. V. Viktorov. Neuroprotective properties of nootropic dipeptide GVS-111 in in vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress Bull Exp Biol Med. 130(10):969–972 2000.
Molekul research summary: https://molekul.io/research/noopept-cell-2000. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry