Clinical efficacy of omberacetam in adults with cognitive impairment: a systematic review
S. B. Seredenin, O. S. Levin, Y. V. Vakhitova, M. V. Metlina, A. A. Poromov · 2026 · Russian Journal of Geriatric Medicine. 2026;(3):335–353.
Published 2026-09-06.
Study data at a glance
- Participants or experimental model
- Review reports 18 clinical studies and 1,279 participants; 988 received omberacetam.
- Reported results
- The authors report cognitive improvements across earlier clinical studies, with MMSE changes ranging from +0.6 to +3.5 points. They used a qualitative synthesis and did not perform a meta-analysis because the studies differed substantially.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- This is a review of earlier studies, not a new 1,279-person trial. Its totals are author-reported, not independently deduplicated here.
- Predominantly open-label evidence; the authors call for randomized placebo-controlled trials. The reported score range is not a pooled treatment effect.
- The English abstract mistakenly says omeprazole in its objective; the title, Russian abstract and results identify omberacetam.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Primary-publication abstract and metadata; complete methods not appraised
Source access and review scope
Publisher-deposited Crossref abstract and publication date checked against the Russian primary abstract reproduced by RusMed. Publisher full text could not be retrieved; study-level bias ratings, funding and overlap require full-text review.
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Source type: Journal publication
Citation and original source
Original source: S. B. Seredenin, O. S. Levin, Y. V. Vakhitova, M. V. Metlina, A. A. Poromov. Clinical efficacy of omberacetam in adults with cognitive impairment: a systematic review Russian Journal of Geriatric Medicine. 2026;(3):335–353. 2026.
Molekul research summary: https://molekul.io/research/noopept-systematic-review-2026. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry