The efficacy of add-on treatment with phenotropil in adult patients with locally-induced epilepsy

O. V. Grebeniuk, N. G. Zhukova, V. M. Alifirova · 2014 · Zh Nevrol Psikhiatr Im S S Korsakova. 114(11 Pt 2):27–31

Randomized trialFull text availableSource linked

This is Molekul’s research summary, not the original publication. Educational information only, not medical advice. Seek qualified healthcare help for medical conditions.

What does this source report?

Three-month randomized, double-blind comparison with placebo. The paper reports 32 discontinuations due to adverse events: 12 in each active group and 8 with placebo.

Population and setting: 90 adults with resistant focal epilepsy; three groups of 30, adjunctive to unchanged antiepileptic therapy
Evidence type: Randomized trial
Preparation: See the original report; formulation details require verification.
Source language: Russian unless otherwise indicated
Title provenance: Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.

What are the limitations?

Substantial adverse-event attrition limits interpretation; a favorable abstract is not a complete safety account.
Allocation concealment and missing-data analysis require further appraisal.
Adjunctive epilepsy treatment does not establish efficacy or safety in healthy users.

Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.

Document format: Publisher HTML article

Review depth: Methods and attrition narrative

Source access and review scope

Publisher full-text methods and discontinuation passage checked; independent outcome-table reanalysis not performed.

Recorded source-check date: 2026-10-02. This date does not imply a completed systematic review.

Open original source or index record ↗

DOI: 10.17116/jnevro201411411227-31

Cite and trace this record

Original source: O. V. Grebeniuk, N. G. Zhukova, V. M. Alifirova. The efficacy of add-on treatment with phenotropil in adult patients with locally-induced epilepsy Zh Nevrol Psikhiatr Im S S Korsakova. 114(11 Pt 2):27–31 2014.

Molekul research summary: https://molekul.io/research/phenotropil-epilepsy-2014. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.

Bibliography entry

Related compound profiles

Phenotropil

A phenyl-substituted piracetam analogue connecting early Soviet experimental pharmacology, IMBP development and later clinical studies. Temperature-dependent animal findings, patient trials and healthy-volunteer PK studies address different questions.

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