RESEARCH ATLAS
← Compound index
COMPOUND RECORD / MEXIDOL

MexidolМексидол

PerformanceStressRecovery
Source linked
01 / OVERVIEW

About Mexidol

Names in this research collection

Ethylmethylhydroxypyridine succinate · Emoxypine succinate

A nonpeptide succinate preparation tested as a separate adjunct in Khabarov’s military trauma rehabilitation comparison.

Research background

A nonpeptide succinate preparation tested as a separate adjunct in Khabarov’s military trauma rehabilitation comparison.

What the studies found

Randomized study in people · 2008

Who or what was studied317 screened, 76 selected (61 men and 15 women), 60 analyzed in four groups of 15. Sixteen early discharges.

Reported finding

Reported work-capacity scores rose from 516.0 to 569.3 with Cortexin and from 524.1 to 613.2 with Vinpotropil. Standard care fell from 526.1 to 509.8.

Cortexin · work-capacity score
516.0±21.4 → 569.3±5.2Reported p<0.05 versus standard careDay 1 to day 14. Standard care 526.1±10.2 → 509.8±12.2.
Vinpotropil · work-capacity score
524.1±23.7 → 613.2±19.5Reported p<0.05 versus standard careDay 1 to day 14. Separate treatment arm.
Cortexin · clinician-rated anxiety
13.4±2.1 → 4.5±0.6Day 14. All arms showed some improvement.
All reported results & study design →
Methods, dose & source notes

Study of multiple preparations · Kirov Military Medical Academy candidate dissertation author abstract

Blinding implementation across different routes is unclear. Complete arm flow, attrition by arm and outcome units need the full dissertation.

Cortexin and other adjuncts in military combined-injury rehabilitation ↗

These highlights cover selected studies. Open a source for its methods, reported doses and full context.

Compound class
Nonpeptide comparator
Research collection
Actoprotection & occupational pharmacology · editorial grouping
Research institutions
No institutional affiliation recorded
Source review
Review dates and the material assessed are listed with each publication below.
02 / HOW TO READ THE RESEARCH

Understanding the evidence

Human research

Small arms in a 60-person analysis.

Study methods

Adjunct comparison using anxiety, asthenia and work-capacity measures.

Independent replication

Independent replication is not established in the linked sources.

Source access

Original sources and the exact review scope are linked below.

Safety evidence

The linked experiments do not establish a safe human performance regimen.

Open a topic for the evidence assessment.

More findings, background and history
EVIDENCE REVIEW / 6 OCTOBER 2026

Outstanding review questions

Authenticate the signed institute original and protocol; reconcile group denominators, background treatment and translation. Independent replication and current-product equivalence remain unverified.

Human reports are linked; their presence does not establish effectiveness. Publication records can share participants. Source counts are not trial counts.

Browse original study records ↗
03 / SOURCE RECORDS

Linked sources

Explore the research map and unresolved leads ↗

2008 · Cortexin and other adjuncts in military combined-injury rehabilitationCortexin · work-capacity score: 516.0±21.4 → 569.3±5.2
2008Randomized trialRussian source · see review scope

Cortexin and other adjuncts in military combined-injury rehabilitation

· Kirov Military Medical Academy candidate dissertation author abstract

Format: Author’s abstract transcription. Full dissertation and underlying records unavailable. · Reviewed: Reported methods, results and evidence limitations

I. Yu. Khabarov · Kirov Military Medical Academy candidate dissertation author abstract

Reported work-capacity scores rose from 516.0 to 569.3 with Cortexin and from 524.1 to 613.2 with Vinpotropil. Standard care fell from 526.1 to 509.8.

Findings, study figures and available tables

Reported findings and study design

Reported work-capacity scores rose from 516.0 to 569.3 with Cortexin and from 524.1 to 613.2 with Vinpotropil. Standard care fell from 526.1 to 509.8.

Author-described double-blind randomized adjunctive study. Outcomes at days 7 and 14 included asthenia, anxiety, memory and tapping-based performance. Control included B-vitamin injections.

Dose, route and schedule

Cortexin 10 mg intramuscularly once daily, Mexidol 100 mg intramuscularly once daily, or Vinpotropil one oral capsule three times daily as separate adjuncts. Standard-care comparator included B1 and B6 injections.

Protocol source ↗ · Author’s abstract transcription. Full dissertation and underlying records unavailable.

Reported findings and study figures · Author’s abstract transcription. Full dissertation and underlying records unavailable.
MeasureResultComparison, timing and statistics
Cortexin · work-capacity score516.0±21.4 → 569.3±5.2Day 1 to day 14. Standard care 526.1±10.2 → 509.8±12.2. · Reported p<0.05 versus standard care
Vinpotropil · work-capacity score524.1±23.7 → 613.2±19.5Day 1 to day 14. Separate treatment arm. · Reported p<0.05 versus standard care
Cortexin · clinician-rated anxiety13.4±2.1 → 4.5±0.6Day 14. All arms showed some improvement.
Attrition16 early discharges; zero attributed to adverse effectsThe abstract does not provide a comprehensive adverse-event table.

This is short-term treatment research in hospitalized patients after trauma. The 60 analyzed are included within the 76 selected.

Source for the extracted data ↗ · Checked 2026-11-09

Population / setting
317 screened, 76 selected (61 men and 15 women), 60 analyzed in four groups of 15. Sixteen early discharges.
What was checked
Author’s abstract transcription. Full dissertation and underlying records unavailable.
Limitations & review scope
  • Blinding implementation across different routes is unclear. Complete arm flow, attrition by arm and outcome units need the full dissertation.

Source checked 2026-11-09. See the review scope above for the material assessed.

Read the source ↗

Follow shared publications or research classes. These links do not establish equivalent effects between compounds.

Cortexin research ↗

1 shared source record

Vinpotropil research ↗

1 shared source record

Research collection curated by @PepMariner · editorial standards. Send a source correction ↗

Browse bibliography & PDFs ↗