Ladasten, the new drug with psychostimulant and anxiolytic actions in treatment of neurasthenia (results of the comparative clinical study with placebo)]
Neznamov GG, Siuniakov SA, Teleshova SE, Chumakov DV, Reutova MA, Siuniakov TS, Mametova LE, Dorofeeva OA, Grishin SA · 2009 · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 109(5):20-26. PMID 19491814
What does this source report?
Single-blind randomized placebo comparison reported symptom improvement. All active-treatment patients completed; only seven placebo participants completed. Missing values were handled using last observation carried forward.
- Population and setting
- 30 patients with neurasthenia; 15 per arm
- Evidence type
- Randomized trial
- Preparation
- See the original report; formulation details require verification.
- Source language
- Russian
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Differential attrition and last-observation-carried-forward analysis can bias estimates.
- Small single-blind comparison with 28-day treatment and one-week follow-up.
- No long-term absence-of-dependence conclusion follows.
- Overlap with related 2009 reports remains unresolved.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Journal article reproduction
Review depth: Methods, attrition and selected tables
Related-report group: ladasten-2009-overlap-unresolved. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original article text reproduced on ResearchGate checked, including randomization and attrition passages; independent statistical reanalysis not performed.
Recorded source-check date: 2026-10-02. This date does not imply a completed systematic review.
Cite and trace this record
Original source: Neznamov GG, Siuniakov SA, Teleshova SE, Chumakov DV, Reutova MA, Siuniakov TS, Mametova LE, Dorofeeva OA, Grishin SA. Ladasten, the new drug with psychostimulant and anxiolytic actions in treatment of neurasthenia (results of the comparative clinical study with placebo)] Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 109(5):20-26. PMID 19491814 2009.
Molekul research summary: https://molekul.io/research/acto-19491814. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry