CCK-4 dipeptide analogue design: opposite behavioral effects of L- and D-tryptophan derivatives
Gudasheva TA, Kir'ianova EP, Kolik LG, Konstantinopol'skiĭ MA, Seredenin SB · 2007 · Bioorg Khim 33:413-420
Reported findings and study design
L-tryptophan derivatives showed anxiety-reducing effects, while D-tryptophan derivatives produced anxiety-like behavior. GB-115 was selected from the L-tryptophan series, with reported rat activity at 0.05–0.2 mg/kg.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Rat anxiety-model activity | 0.05–0.2 mg/kg GB-115; opposite effects in L/D series |
Stereochemical findings are from animal experiments; D-GB-115 and GB-115 must not be treated as the same compound.
Source for the extracted data ↗ · Checked 2026-11-01
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Stereochemical findings are from animal experiments; D-GB-115 and GB-115 must not be treated as the same compound.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Primary indexed English abstract checked.
Source access and review scope
Primary indexed English abstract checked.
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Source type: Original journal publication
Citation and original source
Original source: Gudasheva TA, Kir'ianova EP, Kolik LG, Konstantinopol'skiĭ MA, Seredenin SB. CCK-4 dipeptide analogue design: opposite behavioral effects of L- and D-tryptophan derivatives Bioorg Khim 33:413-420 2007.
Molekul research summary: https://molekul.io/research/gb115-design-2007. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry