Dose-ranging CCK-4 panic-challenge study in healthy volunteers
Bradwejn J, Koszycki D, Bourin M · 1991 · J Psychiatry Neurosci 16:91-95
Reported findings and study design
Panic attacks occurred after CCK-4 in 11%, 17% and 47% of challenges at 9, 25 and 50 micrograms, respectively; none occurred with placebo.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| CCK-4 panic incidence | 11% / 17% / 47% across increasing doses; 0 with placebo |
CCK-4 challenge experiment, not GB-115 administration or an anxiety-treatment trial.
Source for the extracted data ↗ · Checked 2026-11-01
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- CCK-4 challenge experiment, not GB-115 administration or an anxiety-treatment trial.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Primary indexed English abstract checked.
Source access and review scope
Primary indexed English abstract checked.
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Source type: Original journal publication
Citation and original source
Original source: Bradwejn J, Koszycki D, Bourin M. Dose-ranging CCK-4 panic-challenge study in healthy volunteers J Psychiatry Neurosci 16:91-95 1991.
Molekul research summary: https://molekul.io/research/cck4-panic-dose-1991. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry