EpitalonЭпиталон
What is it?
A synthetic four-amino-acid peptide, also called AEDG, developed from pineal-gland peptide research. It is distinct from the tissue extract Epithalamin.
Identity / background source ↗
Research context
A research entry linked to the 2013 short-peptide catalogue and any later publications listed below. The catalogue describes proposed tissue targets; it does not establish clinical efficacy or safety.
- Working classification
- Bioregulator
- Research collection
- Peptide bioregulation · editorial grouping
- Institutional provenance
- Not established for this compound record
- Last evidence review
- Full evidence review pending; source-check scope appears with each publication below.
What do we know?
- Human research
- —Not assessed
- Study methods
- —Not assessed
- Independent replication
- —Not assessed
- Source access
- —See linked publication and review scope
- Safety evidence
- —Not assessed
These are independent review fields, not a rating. Missing evidence in this starter does not mean no research exists.
Linked sources
Explore the research map and unresolved leads ↗
Mechanism of Biological Activity of Short Peptides: Cell Penetration and Epigenetic Regulation of Gene Expression
V. Kh. Khavinson, A. Yu. Solovyev, S. I. Tarnovskaya, N. S. Linkova · Biology Bulletin Reviews 3(6):451–455
Mechanistic review with a table of 15 short peptides on page 453. Tissue labels in the research map are the authors’ proposed targets, not established clinical indications.
- Population / setting
- Review of earlier research
- What was checked
- Author-hosted English PDF and its peptide table checked. Each cited experiment remains a separate appraisal task.
Limitations & review scope
- Source-linked does not mean a completed risk-of-bias review.
- A review is not an independent clinical replication; proposed mechanisms do not establish efficacy or safety.
Source checked 2026-09-27. This is a source-linked record, not a completed evidence review.
Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer’s Disease
Author list available on linked original paper · International Journal of Molecular Sciences 23(8):4259
Develops hypotheses connecting short peptides with gene regulation and neurodegenerative processes. Hypotheses are retained as mechanistic proposals, not clinical conclusions.
- Population / setting
- Review of earlier research
- What was checked
- Source scope and bibliographic record checked; underlying experiments require individual appraisal.
Limitations & review scope
- Source-linked does not mean a completed risk-of-bias review.
- A review is not an independent clinical replication; proposed mechanisms do not establish efficacy or safety.
Source checked 2026-09-27. This is a source-linked record, not a completed evidence review.
Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters
V. Kh. Khavinson, N. S. Linkova, A. I. Rudskoy, M. G. Petukhov · Original article; author-hosted PDF
Examines transporter interactions for 26 ultrashort peptides. Feasibility at this level is not demonstrated oral bioavailability, brain delivery or clinical efficacy.
- Population / setting
- Molecular transport feasibility investigation
- What was checked
- Title, authors and abstract checked; detailed experimental/computational methods await appraisal.
Limitations & review scope
- Source-linked does not mean a completed risk-of-bias review.
- A review is not an independent clinical replication; proposed mechanisms do not establish efficacy or safety.
Source checked 2026-09-27. This is a source-linked record, not a completed evidence review.
Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties
S. K. Araj, J. Brzezik, K. Mądra-Gackowska, Ł. Szeleszczuk · International Journal of Molecular Sciences 26(6):2691
Contemporary review of AEDG/Epitalon chemistry and experimental literature. Epithalamin extract and defined Epitalon peptide are distinguished; evidence for one is not automatically evidence for the other.
- Population / setting
- Review of earlier research
- What was checked
- Source scope and bibliographic record checked; underlying experiments require individual appraisal.
Limitations & review scope
- Source-linked does not mean a completed risk-of-bias review.
- A review is not an independent clinical replication; proposed mechanisms do not establish efficacy or safety.
Source checked 2026-09-27. This is a source-linked record, not a completed evidence review.