Effect of new peptide bioregulators livagen and epitalon on enkephalin-degrading enzymes in human serum
Kost NV, Sokolov OIu, Gabaeva MV, Zolotarev IuA, Malinin VV, Khavinson VKh · 2003 · Izvestiia Akademii nauk. Seriia biologicheskaia 2003
Reported findings and study design
Livagen and Epitalon inhibited enkephalin breakdown in human serum, with IC50 values of 20 and 500 µM respectively. Neither bound the tested µ- or δ-opioid receptors.
Human-serum enzyme assay and rat-brain membrane receptor-binding assay.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Enkephalinase inhibition, IC50 | Livagen 20 µM; Epitalon 500 µM | Concentrations producing 50% inhibition in the serum assay |
| Opioid-receptor binding | No interaction detected at tested µ- or δ-receptors | Rat-brain membrane assay |
These are laboratory concentrations and enzyme endpoints, not evidence of opioid-like clinical effects or an effective human dose.
Source for the extracted data ↗ · Checked 2026-11-01
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- These are laboratory concentrations and enzyme endpoints, not evidence of opioid-like clinical effects or an effective human dose.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Original-publication metadata and indexed abstract checked in Europe PMC. No unavailable full-text figures inferred.
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Source type: Journal publication
Citation and original source
Original source: Kost NV, Sokolov OIu, Gabaeva MV, Zolotarev IuA, Malinin VV, Khavinson VKh. Effect of new peptide bioregulators livagen and epitalon on enkephalin-degrading enzymes in human serum Izvestiia Akademii nauk. Seriia biologicheskaia 2003 2003.
Molekul research summary: https://molekul.io/research/thin-12942748. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Livagen
KEDA tetrapeptide studied in liver-cell cultures, chromatin assays and enkephalin breakdown. In a human-serum assay its enzyme-inhibition IC50 was 20 µM.
Epitalon
Synthetic AEDG has direct human hormone and retinal findings. Long-term Epithalamin mortality studies concern the extract and are kept separate.