The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
Gatta M, Dovizio M, Milillo C, Ruggieri AG, Sallese M, Antonucci I, Trofimov A, Khavinson V, Trofimova S, Bruno A, Ballerini P · 2025 · Stem cell reviews and reports. 2025.
Study findings
Epitalon improved scratch-wound closure and reduced oxidative-stress, epithelial–mesenchymal-transition and fibrosis-related measures in a retinal cell model.
- Population and setting
- High-glucose-exposed ARPE-19 retinal pigment epithelial cells
- Evidence type
- In vitro
- Source language
- eng
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- Cell-culture model, not a clinical diabetic-retinopathy trial.
- Retinal delivery, patient outcomes and clinical safety remain unestablished by this experiment.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Full-text methods and results check
Source access and review scope
Repository full text checked for design, participants and reported outcomes; no independent reanalysis.
Recorded source-check date: 2026-10-08. This date does not imply a completed systematic review.
Citation and original source
Original source: Gatta M, Dovizio M, Milillo C, Ruggieri AG, Sallese M, Antonucci I, Trofimov A, Khavinson V, Trofimova S, Bruno A, Ballerini P. The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy. Stem cell reviews and reports. 2025. 2025.
Molekul research summary: https://molekul.io/research/refresh-40493162. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry