Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line
Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, Mironova E, Pulcini R, Robuffo I, Bologna G, Simeone P, Lanuti P, Guarnieri S, Trofimova S, Procopio AD, Toniato E · 2022 · International journal of molecular sciences 2022
Reported findings and study design
Five preparations reduced LPS-induced TNF and IL-6 expression in differentiated THP-1 cells and reduced adhesion to activated endothelial cells. Chonluten also reduced monocyte TNF release; the full text notes an apoptotic cell fraction with Chonluten.
THP-1 leukemia-derived monocytes, differentiated macrophages and an activated HUVEC endothelial adhesion model.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Inflammatory response | Reduced LPS-stimulated TNF/IL-6 in differentiated cells; reduced monocyte adhesion | |
| Chonluten cell response | Reduced monocyte TNF; an apoptotic fraction also observed | |
| Test concentration | 100 ng/mL per preparation; LPS 100 ng/mL in monocyte/macrophage experiments |
A cell-line experiment, with peptides tested individually. No patient treatment or clinical anti-inflammatory effect was measured. Numerical cytokine reductions are shown graphically rather than supplied as exact data tables.
Source for the extracted data ↗ · Checked 2026-11-01
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- A cell-line experiment, with peptides tested individually. No patient treatment or clinical anti-inflammatory effect was measured. Numerical cytokine reductions are shown graphically rather than supplied as exact data tables.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Full-text XML checked
Source access and review scope
Original full-text XML including methods, results and figure captions checked via Europe PMC. Exact effect sizes were not digitized from graphs.
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Source type: Journal publication
Open original source or index record ↗
DOI: 10.3390/ijms23073607
Citation and original source
Original source: Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, Mironova E, Pulcini R, Robuffo I, Bologna G, Simeone P, Lanuti P, Guarnieri S, Trofimova S, Procopio AD, Toniato E. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line International journal of molecular sciences 2022 2022.
Molekul research summary: https://molekul.io/research/thin-35408963. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Epitalon
Synthetic AEDG has direct human hormone and retinal findings. Long-term Epithalamin mortality studies concern the extract and are kept separate.
Vilon
Defined Lys–Glu (KE) dipeptide with historical adjunct-treatment reports in type 1 diabetes and separate laboratory research. Immune and coagulation-marker findings do not establish autoimmune disease modification.
Thymogen
EW is discussed in the thymus-derived research program. Thymalin extract outcomes cannot be assigned to this defined peptide.
Thymalin
Thymus-derived peptide mixture with historical Russian studies in autoimmune cytopenias and thyroiditis, alongside other treatments. It is distinct from synthetic Thymogen and Thymodepressin.
Chonluten
A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.