AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging
O. M. Ivko, N. S. Linkova, A. R. Ilina, A. A. Sharova, G. A. Ryzhak · 2020 · Adv Gerontol. 33(3):429–435; English translation: Advances in Gerontology 11:53–58 (2021)
Reported findings and study design
The human study reports a 1.7-fold increase in urinary 6-sulfatoxymelatonin, 1.9–2.1-fold normalization of Clock/Csnk1e overexpression and a twofold increase in Cry2 expression.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Urinary 6-sulfatoxymelatonin | 1.7-fold increase | Comparator not specified in the abstract |
| Clock / Csnk1e expression | 1.9–2.1-fold normalization of overexpression | |
| Cry2 expression | 2-fold increase |
The abstract does not specify the comparator for the urinary 1.7-fold figure or provide absolute concentrations. The English translation (10.1134/S2079057021010380) is the same publication, not another trial. The related 2021 World Heart Journal report is grouped because cohort overlap is unresolved.
Source for the extracted data ↗ · Checked 2026-10-31
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- The abstract does not specify the comparator for the urinary 1.7-fold figure or provide absolute concentrations.
- The English translation (10.1134/S2079057021010380) is the same publication, not another trial. The related 2021 World Heart Journal report is grouped because cohort overlap is unresolved.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Primary indexed English abstract checked; full Russian paper and translation not recovered.
Related-report group: epitalon-night-shift-ivko-2020. Reports in this group are not assumed to be independent trials.
Source access and review scope
Primary indexed English abstract checked; full Russian paper and translation not recovered.
Recorded source-check date: 2026-10-31. This date does not imply a completed systematic review.
Citation and original source
Original source: O. M. Ivko, N. S. Linkova, A. R. Ilina, A. A. Sharova, G. A. Ryzhak. AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging Adv Gerontol. 33(3):429–435; English translation: Advances in Gerontology 11:53–58 (2021) 2020.
Molekul research summary: https://molekul.io/research/epitalon-human-ivko-2020. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry