Rhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of the peptide livagen
Brodskiĭ VIa, Khavinson VKh, Zolotarev IuA, Nechaeva NV, Malinin VV, Novikova TE, Gvazava IG, Fateeva VI · 2001 · Izvestiia Akademii nauk. Seriia biologicheskaia 2001
Reported findings and study design
Livagen increased protein synthesis in cultured rat liver cells, most strongly in cells from old animals. Epitalon did not change protein-synthesis intensity in this experiment.
Cultured hepatocytes from rats aged 1–24 months.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Protein synthesis | Increased with Livagen; unchanged with Epitalon | Cultured rat hepatocytes |
| Age range | 1–24 months |
The animals supplied cells; this was not a treatment trial in living rats or people.
Source for the extracted data ↗ · Checked 2026-11-01
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- The animals supplied cells; this was not a treatment trial in living rats or people.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Original-publication metadata and indexed abstract checked in Europe PMC. No unavailable full-text figures inferred.
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Source type: Journal publication
Citation and original source
Original source: Brodskiĭ VIa, Khavinson VKh, Zolotarev IuA, Nechaeva NV, Malinin VV, Novikova TE, Gvazava IG, Fateeva VI. Rhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of the peptide livagen Izvestiia Akademii nauk. Seriia biologicheskaia 2001 2001.
Molekul research summary: https://molekul.io/research/thin-15926314. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Livagen
KEDA tetrapeptide studied in liver-cell cultures, chromatin assays and enkephalin breakdown. In a human-serum assay its enzyme-inhibition IC50 was 20 µM.
Epitalon
Synthetic AEDG has direct human hormone and retinal findings. Long-term Epithalamin mortality studies concern the extract and are kept separate.