[Effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds].
Kuznik BI, Pateiuk AV, Rusaeva NS, Baranchugova LM, Obydenko VI · 2011 · Advances in gerontology = Uspekhi gerontologii · PMID 21809626
What does this source report?
KEDG and AEDG improved thyroid-related hormonal and morphological measures after experimental pituitary removal.
- Population and setting
- Mature and old hypophysectomized birds
- Evidence type
- Animal / experimental
- Preparation
- See the original report; formulation details require verification.
- Source language
- English indexed abstract; original language:
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- This unusual avian model does not demonstrate a testosterone effect or treatment of human hypothyroidism; KEDG is distinct from thyroid extracts.
- Full methods, reporting completeness and independent replication remain to be appraised.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Abstract reviewed
Source access and review scope
Primary citation and indexed abstract reviewed through Europe PMC. Full article not appraised.
Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.
Source provenance: Original journal report
Cite and trace this record
Original source: Kuznik BI, Pateiuk AV, Rusaeva NS, Baranchugova LM, Obydenko VI. [Effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds]. Advances in gerontology = Uspekhi gerontologii · PMID 21809626 2011.
Molekul research summary: https://molekul.io/research/audit-21809626. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Testagen
A defined KEDG tetrapeptide with primary cell/DNA and avian endocrine experiments. Human testosterone or reproductive benefit has not been established in this collection.
Epitalon
AEDG was detected in pineal complex, but the long-term Epithalamin patient studies concern the extract. Synthetic-peptide effects require their own evidence.