Epitalon and Vilon in rat pinealocyte culture
V. Kh. Khavinson, N. S. Linkova, I. M. Kvetnoy, T. V. Kvetnaia, V. O. Polyakova, H.-W. Korf · 2012 · Bulletin of Experimental Biology and Medicine. 2012;153(2):255–258. PMID 22816096.
Indexed 2026-11-11.
Reported findings and study design
Narrative findings; numerical extraction incomplete
Rat pinealocytes were exposed to Epitalon or Vilon, with norepinephrine in additional conditions. The study assessed AANAT, phosphorylated CREB and melatonin in culture medium.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Epitalon and melatonin | Higher melatonin in culture medium reported | |
| AANAT and phosphorylated CREB | Increases with Epitalon; stronger expression with norepinephrine plus peptides |
Source for these results ↗ · Reviewed 2026-11-11
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The abstract does not give arm-level magnitudes, sample sizes or concentrations. It attributes the standalone melatonin increase to Epitalon.
- A culture response cannot establish improved sleep in people.
Source access
Original indexed abstract checked.
Source reviewed 2026-11-11.
Citation and original source
Original source: V. Kh. Khavinson, N. S. Linkova, I. M. Kvetnoy, T. V. Kvetnaia, V. O. Polyakova, H.-W. Korf. Epitalon and Vilon in rat pinealocyte culture Bulletin of Experimental Biology and Medicine. 2012;153(2):255–258. PMID 22816096. 2012.
Molekul research summary: https://molekul.io/research/khavinson-epitalon-vilon-pinealocytes-2012. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Epitalon
Synthetic AEDG has direct human hormone and retinal findings. Long-term Epithalamin mortality studies concern the extract and are kept separate.
Vilon
Defined Lys–Glu (KE) dipeptide with historical adjunct-treatment reports in type 1 diabetes and separate laboratory research. Immune and coagulation-marker findings do not establish autoimmune disease modification.