Effects of short peptides on lymphocyte chromatin in senile subjects
Khavinson VKh, Lezhava TA, Malinin VV · 2004 · Bulletin of experimental biology and medicine 2004
Reported findings and study design
Five short peptides increased ribosomal-gene activity and altered condensed chromatin in sampled leukocytes. Epitalon, Livagen and Prostamax changed chromosome-1 pericentromeric chromatin; Epitalon and Livagen also changed chromosome 9.
Leukocytes sampled from people aged 75–88 years and exposed to peptides in culture.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Chromatin readouts | Ribosomal-gene activation and decondensation reported; no numerical treatment effect supplied | |
| Donor ages | 75–88 years |
People donated cells; they were not treated in a clinical trial. Chromatin changes do not establish rejuvenation or longer life. Related chromatin-program publications may overlap.
Source for the extracted data ↗ · Checked 2026-11-01
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- People donated cells; they were not treated in a clinical trial. Chromatin changes do not establish rejuvenation or longer life. Related chromatin-program publications may overlap.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Related-report group: khavinson-lymphocyte-chromatin-program. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original-publication metadata and indexed abstract checked in Europe PMC. No unavailable full-text figures inferred.
Recorded source-check date: 2026-11-01. This date does not imply a completed systematic review.
Source type: Journal publication
Citation and original source
Original source: Khavinson VKh, Lezhava TA, Malinin VV. Effects of short peptides on lymphocyte chromatin in senile subjects Bulletin of experimental biology and medicine 2004 2004.
Molekul research summary: https://molekul.io/research/thin-15085253. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Vilon
Defined Lys–Glu (KE) dipeptide with historical adjunct-treatment reports in type 1 diabetes and separate laboratory research. Immune and coagulation-marker findings do not establish autoimmune disease modification.
Epitalon
Synthetic AEDG has direct human hormone and retinal findings. Long-term Epithalamin mortality studies concern the extract and are kept separate.
Livagen
KEDA tetrapeptide studied in liver-cell cultures, chromatin assays and enkephalin breakdown. In a human-serum assay its enzyme-inhibition IC50 was 20 µM.
Prostamax
KEDP tetrapeptide investigated in cultured-cell chromatin assays. It increased sister-chromatid exchanges and nucleolar organizer-region activity; prostate symptoms were not measured.
Cortagen
Listed in the 2013 short-peptide review under the authors’ proposed brain target. This historical label is not an established indication. Underlying studies need individual review.