Epitalon did not change melatonin release from perifused rat pineal glands
Y. Djeridane, V. Kh. Khavinson, V. N. Anisimov, Y. Touitou · 2003 · Journal of Endocrinological Investigation. 2003;26(3):211–215. PMID 12809170.
Indexed 2026-11-11.
Reported findings and study design
Narrative findings; numerical extraction incomplete
Perifused glands from young and old male Wistar rats were exposed to AEDG at 1–100 µM. A separate condition tested melatonin secretion stimulated by isoproterenol.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Basal melatonin secretion | No statistically significant effect in either age group | |
| Isoproterenol-stimulated secretion | No change with AEDG reported |
Source for these results ↗ · Reviewed 2026-11-11
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- The abstract does not provide sample sizes, numerical secretion values or confidence intervals.
- This ex vivo preparation differs from dissociated pinealocyte culture and human circadian measurements.
Source access
Original indexed abstract checked.
Source reviewed 2026-11-11.
DOI: 10.1007/BF03345159
Citation and original source
Original source: Y. Djeridane, V. Kh. Khavinson, V. N. Anisimov, Y. Touitou. Epitalon did not change melatonin release from perifused rat pineal glands Journal of Endocrinological Investigation. 2003;26(3):211–215. PMID 12809170. 2003.
Molekul research summary: https://molekul.io/research/djeridane-epitalon-pineal-perifusion-2003. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry