Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro
Lin'kova NS, Drobintseva AO, Orlova OA, Kuznetsova EP, Polyakova VO, Kvetnoy IM, Khavinson VKh · 2016 · Bull Exp Biol Med 161(1):175-178. PMID 27259496
What does this source report?
The peptides altered proliferation, remodeling and aging-associated protein markers. AED and AEDG also reduced caspase-dependent apoptosis in this model.
- Population and setting
- Aging skin-fibroblast cultures; KE, KED, AED and AEDG
- Evidence type
- In vitro
- Preparation
- See the original report; formulation details require verification.
- Source language
- English
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Cultured skin cells, not a human cartilage or longevity trial.
- Changes in Ki-67, CD98hc, MMP-9 and caspase-3 do not establish tissue repair in patients.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed abstract and citation checked via Europe PMC / PubMed; full methods and risk of bias not appraised.
Recorded source-check date: 2026-09-29. This date does not imply a completed systematic review.
Cite and trace this record
Original source: Lin'kova NS, Drobintseva AO, Orlova OA, Kuznetsova EP, Polyakova VO, Kvetnoy IM, Khavinson VKh. Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro Bull Exp Biol Med 161(1):175-178. PMID 27259496 2016.
Molekul research summary: https://molekul.io/research/bio-27259496. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Cartalax
AED research is distinct from PCC. The linked animal and cell papers, and a small patent-reported human comparison, do not establish cartilage regeneration.
Vilon
A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.
Vesugen
A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.
KED
A tripeptide research entry connected to experimental neurodegeneration work. No human benefit is inferred from mouse-model findings.
Epitalon
AEDG was detected in pineal complex, but the long-term Epithalamin patient studies concern the extract. Synthetic-peptide effects require their own evidence.