LCP2 mediates SUV39H1-driven cellular senescence-related chemoresistance in natural killer/T-cell lymphoma.
Zhang Y, Qian S, Yang Q, Shi Z, Dong M, Wang Z, Yang Z, Wu S, Li Z, Zhang M, Zhang X, Chen Q · 2026 · Cell death & disease
Study data at a glance
- Participants or experimental model
- Drug-resistant lymphoma cell models, patient plasma biomarker analysis and an in-vivo experimental model
- Reported results
- The authors report that targeting a senescence-related pathway with Epitalon and Chaetocin partly removed therapy-induced senescent cells and improved chemotherapy response in experimental models. Patient plasma was used for biomarker analysis, not to test Epitalon treatment.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- The abstract discusses Epitalon and Chaetocin together; it does not establish an isolated Epitalon effect or support self-treatment of cancer.
- Animal and laboratory findings do not establish benefit in people.
- Indexed abstract reviewed; complete methods, sample-size details and adverse-event tables have not been assessed.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Publication metadata and indexed abstract checked through Europe PMC on 28 October 2026; full text not appraised.
Recorded source-check date: 2026-10-28. This date does not imply a completed systematic review.
Citation and original source
Original source: Zhang Y, Qian S, Yang Q, Shi Z, Dong M, Wang Z, Yang Z, Wu S, Li Z, Zhang M, Zhang X, Chen Q. LCP2 mediates SUV39H1-driven cellular senescence-related chemoresistance in natural killer/T-cell lymphoma. Cell death & disease 2026.
Molekul research summary: https://molekul.io/research/oct28-42209466. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry