Effect of short peptides on neuronal differentiation of stem cells
Caputi S, Trubiani O, Sinjari B, Trofimova S, Diomede F, Linkova N, Diatlova A, Khavinson V · 2019 · Int J Immunopathol Pharmacol 33:2058738419828613. PMID 30791821
What does this source report?
Examined AED, KED, KE, AEDG and their mixture. Increased neuronal-marker expression was reported for KED and the mixture.
- Population and setting
- Human periodontal-ligament stem-cell cultures
- Evidence type
- In vitro
- Preparation
- See the original report; formulation details require verification.
- Source language
- English
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Mixture results cannot be assigned to AED alone.
- Marker expression is not proof of functional neuronal repair or a human clinical benefit.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Source access and review scope
Indexed abstract and citation checked via Europe PMC / PubMed; full methods and risk of bias not appraised.
Recorded source-check date: 2026-09-29. This date does not imply a completed systematic review.
Cite and trace this record
Original source: Caputi S, Trubiani O, Sinjari B, Trofimova S, Diomede F, Linkova N, Diatlova A, Khavinson V. Effect of short peptides on neuronal differentiation of stem cells Int J Immunopathol Pharmacol 33:2058738419828613. PMID 30791821 2019.
Molekul research summary: https://molekul.io/research/bio-30791821. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Cartalax
AED research is distinct from PCC. The linked animal and cell papers, and a small patent-reported human comparison, do not establish cartilage regeneration.
Vesugen
A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.
KED
A tripeptide research entry connected to experimental neurodegeneration work. No human benefit is inferred from mouse-model findings.
Vilon
A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.
Epitalon
AEDG was detected in pineal complex, but the long-term Epithalamin patient studies concern the extract. Synthetic-peptide effects require their own evidence.