AEDG Peptide Regulates the Expression of Circadian Genes Clock, Cry2, Csnk1e in Human Immune Cells
Vladimir Khavinson, Natalia Linkova, Oleg Ivko · 2021 · World Heart Journal. 13(1):189–191
Reported findings and study design
After 20 days of sublingual AEDG, Cry2 expression doubled from baseline and was 1.2-fold higher than placebo. Csnk1e expression fell 2.1-fold from baseline and was 1.8-fold lower than placebo; all reported comparisons p<0.05.
Dose, route and schedule
Sublingual AEDG solution-spray, 0.5 mg/day for 20 days, versus sublingual 0.9% saline on the same schedule. Historical study methods, not a recommended regimen.
Protocol source ↗ · Original methods
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Participants | 75 women; 40 entered treatment/placebo comparison | 35 normal-melatonin references |
| Cry2 expression | 2-fold higher than baseline; 1.2-fold higher than placebo | p<0.05 |
| Csnk1e expression | 2.1-fold lower than baseline; 1.8-fold lower than placebo | p<0.05 |
Peripheral blood gene-expression markers are not clinical sleep or longevity outcomes. This is a related report to Ivko 2020 and its 2021 English translation; cohort overlap is unresolved, so these reports are grouped rather than counted as independent replication.
Source for the extracted data ↗ · Checked 2026-10-31
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Peripheral blood gene-expression markers are not clinical sleep or longevity outcomes.
- This is a related report to Ivko 2020 and its 2021 English translation; cohort overlap is unresolved, so these reports are grouped rather than counted as independent replication.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Original three-page English article checked; methods and numerical results on pages 189–191.
Related-report group: epitalon-night-shift-ivko-2020. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original three-page English article checked; methods and numerical results on pages 189–191.
Recorded source-check date: 2026-10-31. This date does not imply a completed systematic review.
Citation and original source
Original source: Vladimir Khavinson, Natalia Linkova, Oleg Ivko. AEDG Peptide Regulates the Expression of Circadian Genes Clock, Cry2, Csnk1e in Human Immune Cells World Heart Journal. 13(1):189–191 2021.
Molekul research summary: https://molekul.io/research/epitalon-human-circadian-2021. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry