Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Al-Dulaimi S, Thomas R, Matta S, Roberts T · 2025 · Biogerontology. 2025.
Study findings
Epitalon was associated with telomere extension through telomerase-related changes in normal cells and alternative lengthening of telomeres (ALT) in cancer cell lines.
- Population and setting
- Normal human epithelial/fibroblast cells and 21NT/BT474 breast-cancer cell lines
- Evidence type
- In vitro
- Source language
- eng
- Title source
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
Study limitations
- Cell experiments do not establish human longevity benefits or clinical cancer effects.
- Figures 1–3 were corrected after publication; read the accompanying correction (DOI 10.1007/s10522-025-10326-8).
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Full-text methods and results check
Related-report group: Epitalon telomere study and figure correction. Reports in this group are not assumed to be independent trials.
Source access and review scope
Repository full text checked for design, participants and reported outcomes; no independent reanalysis.
Recorded source-check date: 2026-10-08. This date does not imply a completed systematic review.
Citation and original source
Original source: Al-Dulaimi S, Thomas R, Matta S, Roberts T. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025. 2025.
Molekul research summary: https://molekul.io/research/refresh-40908429. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry