Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.
Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF · 2011 · Biochemistry. Biokhimiia · PMID 22117547
What does this source report?
The paper identifies Testagen as Lys–Glu–Asp–Gly (KEDG). Labeled short peptides entered cells and nuclei; binding patterns differed between DNA sequences.
- Population and setting
- HeLa cells and nucleic-acid fluorescence assays
- Evidence type
- In vitro
- Preparation
- See the original report; formulation details require verification.
- Source language
- English indexed abstract; original language:
- Title provenance
- Title as recorded in the linked source or index. A separate original-language title has not been transcribed unless shown above.
What are the limitations?
- Cell penetration and fluorescence-based binding do not establish hormonal, anti-aging or other clinical effects.
- Full methods, reporting completeness and independent replication remain to be appraised.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Abstract reviewed
Source access and review scope
Primary citation and indexed abstract reviewed through Europe PMC. Full article not appraised.
Recorded source-check date: 2026-10-05. This date does not imply a completed systematic review.
Source provenance: Original journal report
Cite and trace this record
Original source: Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry. Biokhimiia · PMID 22117547 2011.
Molekul research summary: https://molekul.io/research/audit-22117547. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Testagen
A defined KEDG tetrapeptide with primary cell/DNA and avian endocrine experiments. Human testosterone or reproductive benefit has not been established in this collection.
Epitalon
AEDG was detected in pineal complex, but the long-term Epithalamin patient studies concern the extract. Synthetic-peptide effects require their own evidence.
Pinealon
A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.
Bronchogen
Listed in the 2013 short-peptide review under the authors’ proposed bronchi target. This historical label is not an established indication. Underlying studies need individual review.