RESEARCH ATLAS
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COMPOUND RECORD / CHONLUTEN

ChonlutenХонлутен

Source linked

What the studies found

Lab research · 2022

Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line

Study of multiple preparations

Inflammatory response
Reduced LPS-stimulated TNF/IL-6 in differentiated cells; reduced monocyte adhesion
Chonluten cell response
Reduced monocyte TNF; an apoptotic fraction also observed

Five preparations reduced LPS-induced TNF and IL-6 expression in differentiated THP-1 cells and reduced adhesion to activated endothelial cells. Chonluten also reduced monocyte TNF release; the full text notes an apoptotic cell fraction with Chonluten.

Study notes · methods, sources and limitations

Participants or model THP-1 leukemia-derived monocytes, differentiated macrophages and an activated HUVEC endothelial adhesion model.

Design THP-1 leukemia-derived monocytes, differentiated macrophages and an activated HUVEC endothelial adhesion model.

Test concentration
100 ng/mL per preparation; LPS 100 ng/mL in monocyte/macrophage experiments

Important limitations

  • A cell-line experiment, with peptides tested individually. No patient treatment or clinical anti-inflammatory effect was measured. Numerical cytokine reductions are shown graphically rather than supplied as exact data tables.

International journal of molecular sciences 2022 · Journal publication

Original source or citation ↗

Study results and tables ↗

Comparison in people

Chonluten — originating-institute clinical report

Human report located; design quality and independent confirmation remain unresolved.

Study notes · methods, sources and limitations

Participants or model 23 treated bronchitis patients and 19 controls

Important limitations

  • Commercially distributed institute report; independent peer review, randomization and blinding not established. Product composition is not independently characterized here; do not equate a marketed formulation with a purified experimental sequence. Reported absence of harms does not establish safety.

Reports on clinical studies of CYTOMAX and CYTOGEN products; PDF page 123 · Institute report / commercial reproduction

Original source or citation ↗

Study results and tables ↗

Laboratory analysis · 2020

Identification of short peptides in the composition of polypeptide complexes isolated from animal organs

Study of multiple preparations

Reports KED in vessel complex, AED in cartilage, EDG and AEDL in bronchial mucosa, EDR in brain and KEDW in pancreas. This strengthens sequence-level links in the research program.

Study notes · methods, sources and limitations

Participants or model Animal-organ polypeptide complexes analyzed by UHPLC–MS

Important limitations

  • Molecular detection does not prove identical pharmacology or clinical equivalence. The paper’s discussion of clinical work is not an independent clinical trial.

Uspekhi Sovremennoi Biologii 140(2):140–148 · Publication record

Original source or citation ↗

Study results and tables ↗
01 / OVERVIEW

About Chonluten

Names in this research collection

EDG

A short peptide containing three amino acids, listed in the 2013 bioregulator catalogue in connection with respiratory-system function. This is a research target, not an established treatment benefit.

Identity / background source ↗

Research background

A peptide research entry in the Khavinson evidence map. Direct studies, related extract findings, institute reports and unresolved claims are distinguished below.

Compound class
Short peptide research
Research collection
Peptide bioregulation · editorial grouping
Research institutions
No institutional affiliation recorded
Source review
Review dates and the material assessed are listed with each publication below.
02 / HOW TO READ THE RESEARCH

Understanding the evidence

Human research

Institute product report; journal clinical evidence not established

Study methods

Mechanistic review / source table

Independent replication

Independent replication not established by this collection

Source access

See source-specific abstracts, institute reports and explicit review scopes

Safety evidence

Incomplete assessment; findings do not establish safety for personal use

Open a topic for the evidence assessment.

More findings, background and history

What remains unclear

The original report and protocol would clarify group sizes, background treatment and translation. Independent replication and equivalence to current products remain uncertain.

Human reports are linked; their presence does not establish effectiveness. Several publications can describe the same participants.

Browse original study records ↗
PEPTIDE RESEARCH / OCT 2026

Related preparations and evidence

Evidence belongs to the preparation actually studied. A tissue extract and a synthetic peptide can belong to the same research tradition without having equivalent effects or safety.

Bronchial mucosa: the molecular link

Bronchial-mucosa polypeptide complex → Chonluten / EDG; Bronchogen / AEDL

The 2020 UHPLC–MS report identifies EDG and AEDL in bronchial-mucosa complex.

Clinical evidence and limitations

A Chonluten institute product report is now linked in the evidence map; its formulation is not independently characterized. The original 2014 Bronchogen report includes 58 adjunctive oral-capsule patients and 20 standard-care controls, with clinical lung-volume measurements.

Recover sequence-specific original experiments and clinical protocols; effects on respiratory disease and hazardous-exposure protection remain uncertain.

Related preparations

Bronchogen ↗

Some references concern related extracts, reviews or molecular identification rather than direct studies of this compound.

Identification of short peptides in the composition of polypeptide complexes isolated from animal organs ↗Mechanism of Biological Activity of Short Peptides: Cell Penetration and Epigenetic Regulation of Gene Expression ↗

Explore the full bioregulator collection ↗

View this preparation in the Khavinson evidence map ↗

Patent identity check

A 2013 peptide review labels Chonluten as a tripeptide but cites EP1758922, whose family claims the AEDL tetrapeptide associated with Bronchogen. This citation does not establish a patent match for EDG Chonluten. The sequence-specific match remains unresolved.

2013 review and its references ↗ · Read the AEDL patent claim →

03 / SOURCE RECORDS

Linked sources

Explore the research map and unresolved leads ↗

2022 · Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell LineInflammatory response: Reduced LPS-stimulated TNF/IL-6 in differentiated cells; reduced monocyte adhesion
2022In vitroFull text available

Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line

Defined peptides and Thymalin peptide complex tested separately · Journal publication

Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, Mironova E, Pulcini R, Robuffo I, Bologna G, Simeone P, Lanuti P, Guarnieri S, Trofimova S, Procopio AD, Toniato E · International journal of molecular sciences 2022

Five preparations reduced LPS-induced TNF and IL-6 expression in differentiated THP-1 cells and reduced adhesion to activated endothelial cells. Chonluten also reduced monocyte TNF release; the full text notes an apoptotic cell fraction with Chonluten.

Results and tables

Reported findings and study design

Five preparations reduced LPS-induced TNF and IL-6 expression in differentiated THP-1 cells and reduced adhesion to activated endothelial cells. Chonluten also reduced monocyte TNF release; the full text notes an apoptotic cell fraction with Chonluten.

THP-1 leukemia-derived monocytes, differentiated macrophages and an activated HUVEC endothelial adhesion model.

Results · Original full-text XML: Results 2.1–2.5 and Methods; exact graph heights not inferred
MeasureResultComparison, timing and statistics
Inflammatory responseReduced LPS-stimulated TNF/IL-6 in differentiated cells; reduced monocyte adhesion
Chonluten cell responseReduced monocyte TNF; an apoptotic fraction also observed
Test concentration100 ng/mL per preparation; LPS 100 ng/mL in monocyte/macrophage experiments

A cell-line experiment, with peptides tested individually. No patient treatment or clinical anti-inflammatory effect was measured. Numerical cytokine reductions are shown graphically rather than supplied as exact data tables.

Source for these results ↗ · Reviewed 2026-11-01

Population / setting
THP-1 leukemia-derived monocytes, differentiated macrophages and an activated HUVEC endothelial adhesion model.
Source reviewed
Original full-text XML including methods, results and figure captions checked via Europe PMC. Exact effect sizes were not digitized from graphs.
Study limitations
  • A cell-line experiment, with peptides tested individually. No patient treatment or clinical anti-inflammatory effect was measured. Numerical cytokine reductions are shown graphically rather than supplied as exact data tables.

Reviewed 2026-11-01.

Read the source ↗
· Chonluten — originating-institute clinical report
Year unconfirmedHuman comparative studyFull text available

Chonluten — originating-institute clinical report

Marketed product / formulation not independently verified · Institute report / commercial reproduction

Originating institute; report reproduced in commercial collection · Reports on clinical studies of CYTOMAX and CYTOGEN products; PDF page 123

Human report located; design quality and independent confirmation remain unresolved.

Population / setting
23 treated bronchitis patients and 19 controls
Source reviewed
Relevant report text checked in the 125-page PDF edition; not the reported unlocated 152-page edition.
Study limitations
  • Commercially distributed institute report; independent peer review, randomization and blinding not established.
  • Product composition is not independently characterized here; do not equate a marketed formulation with a purified experimental sequence.
  • Reported absence of harms does not establish safety.

Reviewed 2026-09-30.

Read the source ↗
2020 · Identification of short peptides in the composition of polypeptide complexes isolated from animal organs
2020Analytical / composition studyRussian source · see review scope

Identification of short peptides in the composition of polypeptide complexes isolated from animal organs

I. K. Zhurkovich, N. G. Kovrov, G. A. Ryzhak, E. S. Mironova, V. Kh. Khavinson · Uspekhi Sovremennoi Biologii 140(2):140–148

Reports KED in vessel complex, AED in cartilage, EDG and AEDL in bronchial mucosa, EDR in brain and KEDW in pancreas. This strengthens sequence-level links in the research program.

Population / setting
Animal-organ polypeptide complexes analyzed by UHPLC–MS
Source reviewed
Author-hosted Russian PDF: citation and indexed abstract checked; full analytical validation and product-batch equivalence not appraised.
Study limitations
  • Molecular detection does not prove identical pharmacology or clinical equivalence.
  • The paper’s discussion of clinical work is not an independent clinical trial.

Reviewed 2026-09-29.

Read the source ↗
2013 · Mechanism of Biological Activity of Short Peptides: Cell Penetration and Epigenetic Regulation of Gene Expression
2013ReviewFull text available

Mechanism of Biological Activity of Short Peptides: Cell Penetration and Epigenetic Regulation of Gene Expression

V. Kh. Khavinson, A. Yu. Solovyev, S. I. Tarnovskaya, N. S. Linkova · Biology Bulletin Reviews 3(6):451–455

Mechanistic review with a table of 15 short peptides on page 453. Tissue labels in the research map are the authors’ proposed targets, not established clinical indications.

Population / setting
Review of earlier research
Source reviewed
Author-hosted English PDF and its peptide table checked. Each cited experiment remains a separate appraisal task.
Study limitations
  • Source-linked does not mean a completed risk-of-bias review.
  • A review is not an independent clinical replication; proposed mechanisms do not establish efficacy or safety.

Reviewed 2026-09-27.

Read the source ↗

Follow shared publications or research classes. These links do not establish equivalent effects between compounds.

Bronchogen research ↗

2 shared source records

Cartalax research ↗

2 shared source records

Epitalon research ↗

2 shared source records

Pancragen research ↗

2 shared source records

Research collection curated by @PepMariner · editorial standards. Send a source correction ↗

Browse bibliography & PDFs ↗