COMPOUND RECORD / MS13-1

Ms13-1Пептид Ms13-1

Cognition

Source linked

01 / OVERVIEW

About Ms13-1

A peptide isolated from the sea anemone Metridium senile. Its Cys-ladder structure and ASIC1a-potentiating activity make it an experimental probe of acid sensing and pain.

Identity / background source ↗

Research background

A sea-anemone peptide from Metridium senile with a Cys-ladder fold. It potentiates ASIC1a and produced pain-related behavior in mice; it is studied as a channel probe.

What the studies found

Animal research · 2025

Who or what was studiedASIC1a electrophysiology, structural analysis and mouse hind-paw pain model

Reported finding

Ms13-1 potentiated ASIC1a responses to acidic stimuli and produced prolonged pain-related behavior in mice. The peptide has a Cys-ladder fold and serves as a tool for studying channel function.

Methods, dose & source notes

Study of this preparation · Indexed abstract; full methods not assessed

This is a pain-provoking experimental ligand, not evidence of stroke protection or analgesic benefit. Indexed abstract checked; complete methods, tables and independent replication have not been appraised.

Sea anemone Cys-ladder peptide Ms13-1 induces a pain response as a positive modulator of acid-sensing ion channel 1a. ↗

These highlights cover selected studies. Open a source for its methods, reported doses and full context.

Compound class: Marine ion-channel peptide
Research collection: Neuropeptide research · editorial grouping
Research institutions: No institutional affiliation recorded
Source review: Review dates and the material assessed are listed with each publication below.

02 / HOW TO READ THE RESEARCH

Understanding the evidence

Human research No human treatment study in the linked record
Study methods Channel assays and mouse experiments
Independent replication Independent replication not established in this collection
Source access Indexed original abstract; review scope shown per source
Safety evidence Experimental findings do not establish human safety

Open a topic for the evidence assessment.

More findings, background and history

Ion-channel peptide research

These peptides act on different channels and can have opposite effects. Ms13-1 is a pain-provoking research probe; it should not be grouped with protective findings. M2IP is an international comparator.

Targets and experimental findings
Peptide	Target	Research context
APHC peptides	TRPV1	Channel modulation; experimental pain research
Ueq 12-1	TRPA1	A separate sea-anemone TRPA1 ligand
HCIQ2c1	TRPA1	Open-state stabilization and restricted hyperactivation; mouse pain and inflammation findings
Hcr ASIC peptides	ASIC1a	Inhibitory peptide research
Ms13-1	ASIC1a	Positive modulation; induced pain-related behavior in mice
M2IP	TRPM2	International comparator; inhibition and mouse ischemic-injury findings

Channel assays and animal experiments do not establish clinical effectiveness or safety. Each profile links the relevant source and its review scope.

EVIDENCE REVIEW / 6 OCTOBER 2026

Outstanding review questions

Retrieve the full electrophysiology, concentration-response and mouse pain methods. This is a potentiating probe; do not infer neuroprotection from ASIC1a inhibition studies.

No human intervention report has been identified among the linked records; unclassified archival leads may remain. Publication records can share participants. Source counts are not trial counts.

Browse original study records ↗

03 / SOURCE RECORDS

Linked sources

Explore the research map and unresolved leads ↗

2025 · Sea anemone Cys-ladder peptide Ms13-1 induces a pain response as a positive modulator of acid-sensing ion channel 1a.

2025Animal / experimentalEnglish abstract

Sea anemone Cys-ladder peptide Ms13-1 induces a pain response as a positive modulator of acid-sensing ion channel 1a.

Khasanov TA, Mineev KS, Kalinovskii AP, Korolkova YV, Palikov VA, Palikova YA, Dyachenko IA, Kozlov SA, Andreev YA, Osmakov DI · The FEBS journal (2025); PMID 39964805

Ms13-1 potentiated ASIC1a responses to acidic stimuli and produced prolonged pain-related behavior in mice. The peptide has a Cys-ladder fold and serves as a tool for studying channel function.

Population / setting: ASIC1a electrophysiology, structural analysis and mouse hind-paw pain model
What was checked: Original publication metadata and indexed abstract checked via Europe PMC; no full-text appraisal.

Limitations & review scope

This is a pain-provoking experimental ligand, not evidence of stroke protection or analgesic benefit.
Indexed abstract checked; complete methods, tables and independent replication have not been appraised.

Source checked 2026-10-17. See the review scope above for the material assessed.

Read the source ↗

Follow shared publications or research classes. These links do not establish equivalent effects between compounds.

HCIQ2c1 research ↗

Marine ion-channel peptide

Research collection curated by @PepMariner · editorial standards. Send a source correction ↗

Browse bibliography & PDFs ↗