COMPOUND RECORD / HCIQ2C1

HCIQ2c1Пептид HCIQ2c1

Recovery

Source linked

01 / OVERVIEW

About HCIQ2c1

A Kunitz-type peptide from the sea anemone Heteractis magnifica, investigated for serine-protease inhibition and TRPA1 channel-state modulation.

Identity / background source ↗

Research background

A Kunitz-type peptide from Heteractis magnifica. Experimental work links TRPA1 state modulation with reduced chemically induced pain and inflammation in mice.

What the studies found

Animal research · 2024

Who or what was studiedRat TRPA1 expressed in Xenopus oocytes, NMR and mouse pain/inflammation models

Reported finding

HCIQ2c1 reduced chemically induced pain and inflammation in mice. Channel recordings supported stabilization of open TRPA1 and restriction of a hyperactivated state, rather than simple channel blockade.

Methods, dose & source notes

Study of this preparation · Indexed abstract; full methods not assessed

Channel-state modeling and mouse responses do not establish human analgesic efficacy or safety. Published December 2024; not a 2025 discovery. Indexed abstract checked; complete methods, tables and independent replication have not been appraised.

Sea Anemone Kunitz Peptide HCIQ2c1: Structure, Modulation of TRPA1 Channel, and Suppression of Nociceptive Reaction In Vivo. ↗

These highlights cover selected studies. Open a source for its methods, reported doses and full context.

Compound class: Marine ion-channel peptide
Research collection: Neuropeptide research · editorial grouping
Research institutions: No institutional affiliation recorded
Source review: Review dates and the material assessed are listed with each publication below.

02 / HOW TO READ THE RESEARCH

Understanding the evidence

Human research No human treatment study in the linked record
Study methods Channel assays and mouse experiments
Independent replication Independent replication not established in this collection
Source access Indexed original abstract; review scope shown per source
Safety evidence Experimental findings do not establish human safety

Open a topic for the evidence assessment.

More findings, background and history

Ion-channel peptide research

These peptides act on different channels and can have opposite effects. Ms13-1 is a pain-provoking research probe; it should not be grouped with protective findings. M2IP is an international comparator.

Targets and experimental findings
Peptide	Target	Research context
APHC peptides	TRPV1	Channel modulation; experimental pain research
Ueq 12-1	TRPA1	A separate sea-anemone TRPA1 ligand
HCIQ2c1	TRPA1	Open-state stabilization and restricted hyperactivation; mouse pain and inflammation findings
Hcr ASIC peptides	ASIC1a	Inhibitory peptide research
Ms13-1	ASIC1a	Positive modulation; induced pain-related behavior in mice
M2IP	TRPM2	International comparator; inhibition and mouse ischemic-injury findings

Channel assays and animal experiments do not establish clinical effectiveness or safety. Each profile links the relevant source and its review scope.

EVIDENCE REVIEW / 6 OCTOBER 2026

Outstanding review questions

Appraise the full 2024 paper for channel-state assays, doses, masking and adverse effects. Separate molecular modeling from measured TRPA1 effects and mouse behavior.

No human intervention report has been identified among the linked records; unclassified archival leads may remain. Publication records can share participants. Source counts are not trial counts.

Browse original study records ↗

03 / SOURCE RECORDS

Linked sources

Explore the research map and unresolved leads ↗

2024 · Sea Anemone Kunitz Peptide HCIQ2c1: Structure, Modulation of TRPA1 Channel, and Suppression of Nociceptive Reaction In Vivo.

2024Animal / experimentalEnglish abstract

Sea Anemone Kunitz Peptide HCIQ2c1: Structure, Modulation of TRPA1 Channel, and Suppression of Nociceptive Reaction In Vivo.

Kvetkina AN, Oreshkov SD, Mironov PA, Zaigraev MM, Klimovich AA, Deriavko YV, Menshov AS, Kulbatskii DS, Logashina YA, Andreev YA, Chugunov AO, Kirpichnikov MP, Lyukmanova EN, Leychenko EV, Shenkarev ZO · Marine drugs (2024); PMID 39728117

Population / setting: Rat TRPA1 expressed in Xenopus oocytes, NMR and mouse pain/inflammation models
What was checked: Original publication metadata and indexed abstract checked via Europe PMC; no full-text appraisal.

Limitations & review scope

Channel-state modeling and mouse responses do not establish human analgesic efficacy or safety. Published December 2024; not a 2025 discovery.
Indexed abstract checked; complete methods, tables and independent replication have not been appraised.

Source checked 2026-10-17. See the review scope above for the material assessed.

Read the source ↗

Follow shared publications or research classes. These links do not establish equivalent effects between compounds.

Ms13-1 research ↗

Marine ion-channel peptide

Research collection curated by @PepMariner · editorial standards. Send a source correction ↗

Browse bibliography & PDFs ↗