COMPOUND RECORD / APHC-PEPTIDES

APHC peptide familyПептиды APHC

StressCognition

Source linked

Research profile Published findings and original sources.

01 / OVERVIEW

What is it?

Research context

Sea-anemone-derived peptides studied as TRPV1 modulators. APHC3 has mouse stress-behavior and hippocampal plasticity research; results are specific to the tested peptide.

Selected study findings

animal · 2026

Study of this preparation · Publication record; consult source access and review depth

Mouse behavior and hippocampal preparations

APHC3 enhanced hippocampal long-term potentiation in mouse preparations and produced anxiolytic-like effects in acute-stress behavioral tests.

Limit: Mouse and brain-slice experiments, not human anxiety treatment evidence. Intranasal administration does not itself prove brain delivery; peptide levels in brain tissue were not directly quantified.

Peptide Modulator of TRPV1 Channel Increases Long-Term Potentiation in the Hippocampus and Reduces Anxiety and Fear in Mice Under Acute Stress ↗

Selected findings. Study-specific limitations and preparation details accompany each source.

Compound class: Marine peptide research
Research collection: Neuropeptide research · editorial grouping
Research institutions: No institutional affiliation recorded
Source review: Review dates and the material assessed are listed with each publication below.

02 / EVIDENCE DIMENSIONS

Evidence assessment

Human research: —No human intervention study established in this collection
Study methods: —Animal and/or laboratory experiments; see individual sources
Independent replication: —Independent replication not assessed
Source access: —Original publication records linked
Safety evidence: —Human dosing and clinical safety are not established

Evidence assessed by study design, replication, source access and safety reporting.

Research context, history and detailed findings

EVIDENCE REVIEW / 6 OCTOBER 2026

Outstanding review questions

Appraise original methods and replication; keep animal and cell findings separate from unestablished human benefit and safety.

No human intervention report has been identified among the linked records; unclassified archival leads may remain. Publication records can share participants. Source counts are not trial counts.

View the collection-wide research audit ↗

03 / SOURCE RECORDS

Linked sources

Explore the research map and unresolved leads ↗

2026 · Peptide Modulator of TRPV1 Channel Increases Long-Term Potentiation in the Hippocampus and Reduces Anxiety and Fear in Mice Under Acute Stress

2026Animal / experimentalFull text available

Peptide Modulator of TRPV1 Channel Increases Long-Term Potentiation in the Hippocampus and Reduces Anxiety and Fear in Mice Under Acute Stress

· Marine Drugs. 2026;24(2):59.

APHC3 enhanced hippocampal long-term potentiation in mouse preparations and produced anxiolytic-like effects in acute-stress behavioral tests.

Population / setting: Mouse behavior and hippocampal preparations
What was checked: Repository primary abstract checked; full-text resource retrieved. Detailed tables not independently appraised.

Limitations & review scope

Mouse and brain-slice experiments, not human anxiety treatment evidence.
Intranasal administration does not itself prove brain delivery; peptide levels in brain tissue were not directly quantified.

Source checked 2026-10-11. See the review scope above for the material assessed.

Read the source ↗

Browse bibliography & PDFs ↗