Sea anemone Cys-ladder peptide Ms13-1 induces a pain response as a positive modulator of acid-sensing ion channel 1a.
Khasanov TA, Mineev KS, Kalinovskii AP, Korolkova YV, Palikov VA, Palikova YA, Dyachenko IA, Kozlov SA, Andreev YA, Osmakov DI · 2025 · The FEBS journal (2025); PMID 39964805
Study data at a glance
- Participants or experimental model
- ASIC1a electrophysiology, structural analysis and mouse hind-paw pain model
- Reported results
- Ms13-1 potentiated ASIC1a responses to acidic stimuli and produced prolonged pain-related behavior in mice. The peptide has a Cys-ladder fold and serves as a tool for studying channel function.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- This is a pain-provoking experimental ligand, not evidence of stroke protection or analgesic benefit.
- Indexed abstract checked; complete methods, tables and independent replication have not been appraised.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Original publication metadata and indexed abstract checked via Europe PMC; no full-text appraisal.
Recorded source-check date: 2026-10-17. This date does not imply a completed systematic review.
Open original source or index record ↗
DOI: 10.1111/febs.70032
Citation and original source
Original source: Khasanov TA, Mineev KS, Kalinovskii AP, Korolkova YV, Palikov VA, Palikova YA, Dyachenko IA, Kozlov SA, Andreev YA, Osmakov DI. Sea anemone Cys-ladder peptide Ms13-1 induces a pain response as a positive modulator of acid-sensing ion channel 1a. The FEBS journal (2025); PMID 39964805 2025.
Molekul research summary: https://molekul.io/research/oct17-39964805. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry