Sea Anemone Kunitz Peptide HCIQ2c1: Structure, Modulation of TRPA1 Channel, and Suppression of Nociceptive Reaction In Vivo.
Kvetkina AN, Oreshkov SD, Mironov PA, Zaigraev MM, Klimovich AA, Deriavko YV, Menshov AS, Kulbatskii DS, Logashina YA, Andreev YA, Chugunov AO, Kirpichnikov MP, Lyukmanova EN, Leychenko EV, Shenkarev ZO · 2024 · Marine drugs (2024); PMID 39728117
Study data at a glance
- Participants or experimental model
- Rat TRPA1 expressed in Xenopus oocytes, NMR and mouse pain/inflammation models
- Reported results
- HCIQ2c1 reduced chemically induced pain and inflammation in mice. Channel recordings supported stabilization of open TRPA1 and restriction of a hyperactivated state, rather than simple channel blockade.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Channel-state modeling and mouse responses do not establish human analgesic efficacy or safety. Published December 2024; not a 2025 discovery.
- Indexed abstract checked; complete methods, tables and independent replication have not been appraised.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Review depth: Indexed abstract checked
Source access and review scope
Original publication metadata and indexed abstract checked via Europe PMC; no full-text appraisal.
Recorded source-check date: 2026-10-17. This date does not imply a completed systematic review.
Open original source or index record ↗
DOI: 10.3390/md22120542
Citation and original source
Original source: Kvetkina AN, Oreshkov SD, Mironov PA, Zaigraev MM, Klimovich AA, Deriavko YV, Menshov AS, Kulbatskii DS, Logashina YA, Andreev YA, Chugunov AO, Kirpichnikov MP, Lyukmanova EN, Leychenko EV, Shenkarev ZO. Sea Anemone Kunitz Peptide HCIQ2c1: Structure, Modulation of TRPA1 Channel, and Suppression of Nociceptive Reaction In Vivo. Marine drugs (2024); PMID 39728117 2024.
Molekul research summary: https://molekul.io/research/oct17-39728117. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry