Bolekhan’s dissertation on Bemitil and immunomodulators in lung inflammation
A. V. Bolekhan · 2006 · Kirov Military Medical Academy. Candidate dissertation, St. Petersburg, 2006. The author names Project Talent, 4.04.133.п.12.
Indexed 2026-11-11.
Related evidence maps: Military & occupational ↗
Reported findings and study design
Narrative findings; numerical extraction incomplete
Compared the three drugs and Bemitil combinations in rat bronchopulmonary inflammation, with lung histology, ATP and other metabolites, and phagocyte and lymphocyte endpoints.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Metabolic markers | Lower lactate, ADP and AMP; higher pyruvate and ATP | Reported for the immunomodulators and their Bemitil combinations. |
| Relative individual activity | Bemitil led selected energy measures; Polyoxidonium led selected immunotropic measures | |
| Cellular respiration markers | Bemitil increased flavoprotein fluorescence and lowered reduced pyridine nucleotide fluorescence | In alveolar macrophages and blood lymphocytes. The other agents and the combinations did not show the same pattern. |
| Combination outcomes | Greater reported changes in selected metabolic and immune markers | The accessible transcription does not provide numerical estimates or an interaction analysis. |
Source for these results ↗ · Reviewed 2026-11-11
For research and education. Consult a qualified clinician for medical advice.
Study limitations and source details
Study limitations
- Complete group tables, arm denominators and the separate Project Talent report require recovery.
- Related papers from the same laboratory may share animals or assays. No separate cohort is inferred.
Source access
Dissertation contents, introduction and conclusions in Russian transcription.
Source reviewed 2026-11-11.
Source type: Dissertation excerpts
Citation and original source
Original source: A. V. Bolekhan. Bolekhan’s dissertation on Bemitil and immunomodulators in lung inflammation Kirov Military Medical Academy. Candidate dissertation, St. Petersburg, 2006. The author names Project Talent, 4.04.133.п.12. 2006.
Molekul research summary: https://molekul.io/research/bolekhan-bronchopulmonary-inflammation-2006. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
Bemitil
A benzimidazole-derived actoprotector, also indexed as bemethyl and Metaprot. Research spans patient asthenia, occupational settings, neuromuscular and liver studies, metabolism and preclinical safety; these are research contexts, not established uses.
Trekrezan
A research lineage linking synthetic adaptogen chemistry with Kirov environmental-stress and immune-metabolism programs. Human cold-exposure work, animal hypoxia studies and experimental combinations are distinguished below.
Polyoxidonium
Azoximer bromide is a synthetic polymer studied alongside Trekrezan and Bemitil in rat inflammation models and isolated macrophage assays.