RU2496504C1: midbrain peptide fraction in cycling and swimming — RU2496504C1
N. N. Karkishchenko, V. N. Karkishchenko, S. L. Lyublinskiy, A. A. Stepanov · 2013 · RU2496504C1 · patent family 49253700
Published 2013-10-27.
Related evidence maps: Sports performance ↗
Reported patent results
Reported findings
4.2±0.1 to 6.7±0.1 min with B; saline 4.3±0.3 to 4.6±0.5 min. Applicant-reported athlete data.
Example 5 describes 12 cyclists aged 20–22 and 12 swimmers aged 18–20. Each sport had six in the fraction arm and six in the saline arm.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Cyclists · maximal-speed duration | 4.2±0.1 to 6.7±0.1 min with B; saline 4.3±0.3 to 4.6±0.5 min | Days 1 to 21; n=6 per arm. |
| Cyclists · submaximal distance | 7200±130 to 11600±100 m with B; saline 6300±120 to 7100±100 m | Days 1 to 21. |
| Swimmers · endurance | 25.0±1 to 35.0±3 min with B; saline 24.0±2 to 23.0±5 min | Days 1 to 21. |
| Swimmers · speed | 4.85±0.1 to 6.7±0.1 km/h with B; saline 4.9±0.1 to 5.0±0.1 km/h | Days 1 to 21. |
| Reported athlete dose | 10 mg rectally versus saline | Example 5; full dosing frequency and adherence not established. |
| Overlap check | The Fraction B and saline athlete tables largely repeat the earlier filing, with a discrepancy in the final cycling sprint value. Participant identifiers are unavailable; treat these as overlapping disclosures, not independent trials. | Compare the later patent Tables 8–11 with earlier Tables 7–10. |
Table 7 · Cycle sprint to exhaustion (min)
| Group | Day 1 | Day 8 | Day 15 | Day 21 | Day 27 |
|---|---|---|---|---|---|
| Fraction B | 4.2±0.1 | 5.6±0.2 | 6.1±0.3 | 6.7±0.1 | 6.6±0.2 |
| Saline | 4.3±0.3 | 4.5±0.1 | 4.6±0.2 | 4.6±0.5 | 4.5±0.1 |
Six athletes per group within the relevant sport. The filing does not define the uncertainty term or provide a formal interaction test. Day labels and values are as printed.
Table 8 · Cycle distance at about 60% speed (m)
| Group | Day 1 | Day 8 | Day 15 | Day 21 | Day 27 |
|---|---|---|---|---|---|
| Fraction B | 7200±130 | 8900±120 | 10400±120 | 11600±100 | 10900±100 |
| Saline | 6300±120 | 6500±150 | 6900±100 | 7100±100 | 6900±150 |
Six athletes per group within the relevant sport. The filing does not define the uncertainty term or provide a formal interaction test. Day labels and values are as printed.
Table 9 · Front-crawl time to exhaustion (min)
| Group | Day 1 | Day 8 | Day 15 | Day 21 | Day 27 |
|---|---|---|---|---|---|
| Fraction B | 25.0±1 | 27.0±3 | 31.0±2 | 35.0±3 | 34.0±3 |
| Saline | 24.0±2 | 25.0±3 | 24.0±2 | 23.0±5 | 22.0±4 |
Six athletes per group within the relevant sport. The filing does not define the uncertainty term or provide a formal interaction test. Day labels and values are as printed.
Table 10 · Swim speed during five-minute test (km/h)
| Group | Day 1 | Day 8 | Day 15 | Day 21 | Day 27 |
|---|---|---|---|---|---|
| Fraction B | 4.85±0.1 | 5.8±0.1 | 6.2±0.1 | 6.7±0.1 | 6.5±0.1 |
| Saline | 4.9±0.1 | 5.0±0.1 | 5.1±0.1 | 5.0±0.1 | 4.7±0.1 |
Six athletes per group within the relevant sport. The filing does not define the uncertainty term or provide a formal interaction test. Day labels and values are as printed.
Applicant-reported comparisons, with unclear randomization, masking, systematic safety reporting and uncertainty definition. This is a distinct tissue fraction; the patent provides no peptide-sequence match to PPK-V.
Source for the extracted data ↗ · Checked 2026-11-08
Patent claims and provenance
Formulation. Claims a 500–900 Da peptide fraction derived from midbrain periaqueductal gray of cattle or pigs, with extraction and administration claims.
Corresponds to the Fraction B preparation in the companion filing; overlapping data are not independent confirmation.
- Publication
- RU2496504C1 ↗ · 2013-10-27
- Earliest priority / filing
- 2012-03-22 / 2012-03-22
- Original applicant / assignee
- Scientific Center for Biomedical Technologies, Russian Academy of Medical Sciences
- Indexed status
- Not shown; official status unverified · checked 2026-11-08
- Patent family
- 49253700 · family publications are related filings, not independent studies.
Original title, inventors and related publications
Средство для стимуляции работы в экстремальных условиях, способ его получения и его применения
Inventors: N. N. Karkishchenko; V. N. Karkishchenko; S. L. Lyublinskiy; A. A. Stepanov.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- Corresponds to the Fraction B preparation in the companion filing; overlapping data are not independent confirmation.
- Applicant-reported comparisons, with unclear randomization, masking, systematic safety reporting and uncertainty definition. This is a distinct tissue fraction; the patent provides no peptide-sequence match to PPK-V.
- Patents record claimed inventions and supporting disclosures. Publication or grant does not establish clinical efficacy, safety or marketing approval. Members of one patent family and related journal reports can describe the same experiments.
- Status labels are Google Patents index snapshots for the displayed publication or application; the record gives its source-check date. Official registers and every national family member have not been independently checked. These labels do not establish freedom to operate.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original patent text and indexed metadata
Review depth: Claims, athlete methods and complete athlete tables compared across the two filings; scans unavailable
Related-report group: karkishchenko-athlete-disclosures-overlap. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original patent publication accessed through Google Patents. Claims, selected reported findings and source limitations checked. The results section identifies the examples, tables and any numerical extraction gaps. No complete experimental audit, prosecution review or legal claim construction was performed.
Recorded source-check date: 2026-11-08. This date does not imply a completed systematic review.
Source type: Patent publication
Citation and original source
Original source: N. N. Karkishchenko, V. N. Karkishchenko, S. L. Lyublinskiy, A. A. Stepanov. RU2496504C1: midbrain peptide fraction in cycling and swimming — RU2496504C1 RU2496504C1 · patent family 49253700 2013.
Molekul research summary: https://molekul.io/research/patent-ru2496504c1. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entry