GHK plus Thymogen: 2012 wound-healing patent — RU2452508C2
Виктор Юрьевич Чердаков, Михаил Юрьевич Смахтин, Григорий Михайлович Дубровин, Игорь Иванович Бобынцев, Максим Евгеньевич Долгинцев, Алексей Анатольевич Крюков, Евгений Николаевич Кононец, Ирина Михайловна Соболева, Яна Вячеславовна Кремзукова, Андрей Евгеньевич Белых, Ольга Игоревна Иванова · 2012 · RU2452508C2 · patent family 46029806
Published 2012-06-10.
Reported patent results
Reported findings
In the intradermal rat comparison, GHK plus Thymogen produced a higher wound-healing coefficient than saline or either peptide alone. No quantitative neutrophil endpoint was disclosed.
Wistar rats with experimental skin wounds; Table 1 has 8 animals/group: saline, copper-free GHK, Thymogen and their combination. Day-10 wound-area assessment.
| Measure | Result | Comparison, timing and statistics |
|---|---|---|
| Relative wound-healing coefficient: combination versus saline | 0.56 ± 0.04 versus 0.29 ± 0.03 | Intradermal GHK plus Thymogen versus saline; 8 rats/group; M±m as printed · Day 10 · p<0.05; Table 1 footnote |
| Single-peptide comparators | GHK 0.44 ± 0.04; Thymogen 0.41 ± 0.03 | Both differed from saline; the combination also differed from each single peptide · Day 10 · p<0.05 for the comparisons marked in Table 1 |
| What the coefficient measures | Change in wound area relative to initial area; not the percentage of animals completely healed | A value of 0.56 corresponds to relative area reduction, not a 56% patient response rate |
| Separate intraperitoneal example | Greater healing with the combination described qualitatively; no separate numerical table supplied | Do not transfer the intradermal effect estimate to another route · Day 10 |
| Neutrophil function and safety | No numerical neutrophil assay or systematic adverse-event results in the disclosed examples | Neutrophil rationale and earlier GHK dose-related immune effects are background discussion, not new measured endpoints |
Animal wound-area results from a combination, not GHK-Cu monotherapy or clinical wound efficacy. Randomization, blinded measurement and a formal synergy interaction test are not described. The preparation called Thymogen is distinct from Thymodepressin.
Source for the extracted data ↗ · Checked 2026-11-07
Patent claims and provenance
Use. The claim combines unbound Gly-His-Lys with Thymogen for skin-wound repair and neutrophil function. The grant publication is C2, not C1.
The numerical table concerns rat wound-area healing after intradermal treatment. It does not establish a measured neutrophil benefit, human wound efficacy or activity of GHK-Cu.
- Publication
- RU2452508C2 ↗ · 2012-06-10
- Earliest priority / filing
- 2010-09-13 / 2010-09-13
- Original applicant / assignee
- Kursk State Medical University
- Indexed status
- IP Right Cessation — indexed historical event; official status unverified · checked 2026-11-07
- Patent family
- 46029806 · family publications are related filings, not independent studies.
Original title, inventors and related publications
Method for stimulating wound healing and functional activity of neutrophils
Inventors: Виктор Юрьевич Чердаков; Михаил Юрьевич Смахтин; Григорий Михайлович Дубровин; Игорь Иванович Бобынцев; Максим Евгеньевич Долгинцев; Алексей Анатольевич Крюков; Евгений Николаевич Кононец; Ирина Михайловна Соболева; Яна Вячеславовна Кремзукова; Андрей Евгеньевич Белых; Ольга Игоревна Иванова.
Molekul summary of the linked publication. Educational information, not medical advice. Seek qualified healthcare help for medical conditions.
Methods, limitations & source review
Study limitations
- The numerical table concerns rat wound-area healing after intradermal treatment. It does not establish a measured neutrophil benefit, human wound efficacy or activity of GHK-Cu.
- Animal wound-area results from a combination, not GHK-Cu monotherapy or clinical wound efficacy. Randomization, blinded measurement and a formal synergy interaction test are not described. The preparation called Thymogen is distinct from Thymodepressin.
- Patents record claimed inventions and supporting disclosures. Publication or grant does not establish clinical efficacy, safety or marketing approval. Members of one patent family and related journal reports can describe the same experiments.
- Status labels are Google Patents index snapshots for the displayed publication or application; the record gives its source-check date. Official registers and every national family member have not been independently checked. These labels do not establish freedom to operate.
Publication counts are not counts of independent trials. Reviews, translations and reports sharing participants may overlap. Findings apply to the studied preparation, population and endpoints.
Document format: Original patent text and indexed metadata
Review depth: Claims, selected reported findings and limitations reviewed; supporting experiments not comprehensively appraised.
Related-report group: patent-family-46029806. Reports in this group are not assumed to be independent trials.
Source access and review scope
Original patent publication accessed through Google Patents. Claims, selected reported findings and source limitations checked. The results section identifies the examples, tables and any numerical extraction gaps. No complete experimental audit, prosecution review or legal claim construction was performed.
Recorded source-check date: 2026-11-07. This date does not imply a completed systematic review.
Source type: Patent publication
Citation and original source
Original source: Виктор Юрьевич Чердаков, Михаил Юрьевич Смахтин, Григорий Михайлович Дубровин, Игорь Иванович Бобынцев, Максим Евгеньевич Долгинцев, Алексей Анатольевич Крюков, Евгений Николаевич Кононец, Ирина Михайловна Соболева, Яна Вячеславовна Кремзукова, Андрей Евгеньевич Белых, Ольга Игоревна Иванова. GHK plus Thymogen: 2012 wound-healing patent — RU2452508C2 RU2452508C2 · patent family 46029806 2012.
Molekul research summary: https://molekul.io/research/patent-ru2452508c2. Cite the original publication for its findings and this page when referring to Molekul’s summary or evidence appraisal.
Bibliography entryRelated compound profiles
GHK-Cu & GHK family
A single research family collecting GHK-Cu, unbound GHK, Russian terminal extensions, stereochemical variants and related delivery constructs. The member map identifies which molecule each source actually studied; a shared card does not establish interchangeable biological activity.
Thymogen
EW is discussed in the thymus-derived research program. Thymalin extract outcomes cannot be assigned to this defined peptide.